CAS IR GRID研究单元&专题: 深圳先进技术研究院中国科学院深圳先进技术研究院(Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences)是由中国科学院、深圳市人民政府及香港中文大学友好协商,在深圳市共同建立的,简称先进院。2006年2月,中国科学院深圳先进技术研究院成立。http://www.irgrid.ac.cn:8080/handle/1471x/3272712024-03-29T15:14:04Z2024-03-29T15:14:04ZVisualization and Quantification of Sortase Activity at the Single-Molecule Level via Transpeptidation-Directed Intramolecular Forster Resonance Energy TransferYang, YongLi, YueyingZhang, Chun-yanghttp://www.irgrid.ac.cn:8080/handle/1471x/23403552019-05-06T01:40:48Z2019-01-31T07:12:06Z题名: Visualization and Quantification of Sortase Activity at the Single-Molecule Level via Transpeptidation-Directed Intramolecular Forster Resonance Energy Transfer
作者: Yang, Yong; Li, Yueying; Zhang, Chun-yang2019-01-31T07:12:06ZAutomatic Prostate Segmentation using Deep Learning and MR ImagesQin, W.Buyyounouski, M. K.Hancock, S. L.Bagshaw, H. P.Han, B.Xing, L.Yuan, Y.http://www.irgrid.ac.cn:8080/handle/1471x/23403522019-05-06T01:40:48Z2019-01-31T07:12:05Z题名: Automatic Prostate Segmentation using Deep Learning and MR Images
作者: Qin, W.; Buyyounouski, M. K.; Hancock, S. L.; Bagshaw, H. P.; Han, B.; Xing, L.; Yuan, Y.2019-01-31T07:12:05ZThermal cycling leads grains to more homogeneous force networks and energy repartitionBai, Dong-YunWang, Xiao-Lianghttp://www.irgrid.ac.cn:8080/handle/1471x/23403542019-05-06T01:40:48Z2019-01-31T07:12:05Z题名: Thermal cycling leads grains to more homogeneous force networks and energy repartition
作者: Bai, Dong-Yun; Wang, Xiao-Liang2019-01-31T07:12:05ZForensic SNP Genotyping with SNaPshot: Development of a Novel In-house SBE Multiplex SNP AssayIsrar, MuhammadWiegand, PeterKulstein, GalinaZar, Mian SahibShahid, Ahmad AliShahzad, Muhammad SaqibShin, Kyoung-JinLee, Hwan YoungLee, Sang-Seobhttp://www.irgrid.ac.cn:8080/handle/1471x/23403532019-05-06T01:40:48Z2019-01-31T07:12:05Z题名: Forensic SNP Genotyping with SNaPshot: Development of a Novel In-house SBE Multiplex SNP Assay
作者: Israr, Muhammad; Wiegand, Peter; Kulstein, Galina; Zar, Mian Sahib; Shahid, Ahmad Ali; Shahzad, Muhammad Saqib; Shin, Kyoung-Jin; Lee, Hwan Young; Lee, Sang-Seob
摘要: This study introduces a newly developed in-house SNaPshot single-base extension (SBE) multiplex assay for forensic single nucleotide polymorphism (SNP) genotyping of fresh and degraded samples. The assay was validated with fresh blood samples from four different populations. In addition, altogether 24 samples from skeletal remains were analyzed with the multiplex. Full SNP profiles could be obtained from 14 specimens, while ten remains showed partial SNP profiles. Minor allele frequencies (MAF) of bone samples and different populations were compared and used for association of skeletal remains with acertain population. The results reveal that the SNPs of the bone samples are genetically close to the Pathan population. The findings show that the new multiplex system can be utilized for SNP genotyping of degraded and forensic relevant skeletal material, enabling to provide additional investigative leads in criminal cases.2019-01-31T07:12:05ZDevelopment of a KNN Ceramic-Based Lead-Free Linear Array Ultrasonic TransducerHumayun, Mark S.Zhang, ZhiqiangChen, RuiminWang, BoZhang, TianfuSu, MinLiu, RongYang, JiaxingCao, XiaodongLi, YongxiangZheng, HairongShung, K. KirkZhou, QifaQiu, Weibaohttp://www.irgrid.ac.cn:8080/handle/1471x/23403512019-05-06T01:40:48Z2019-01-31T07:12:04Z题名: Development of a KNN Ceramic-Based Lead-Free Linear Array Ultrasonic Transducer
作者: Humayun, Mark S.; Zhang, Zhiqiang; Chen, Ruimin; Wang, Bo; Zhang, Tianfu; Su, Min; Liu, Rong; Yang, Jiaxing; Cao, Xiaodong; Li, Yongxiang; Zheng, Hairong; Shung, K. Kirk; Zhou, Qifa; Qiu, Weibao
摘要: High-frequency array transducers can provide higher imaging resolution than traditional transducers, thus resolving smaller features and producing finer images. Commercially available ultrasonic transducers are mostly made with lead-based piezoelectric materials, which are harmful to the environment and public health. This paper presents the development of the 64-elements high-frequency (18.3 MHz) lead-free linear array ultrasonic transducer based on (K0.44Na0.52Li0.04)(Nb0.86Ta0.1Sb0.04)O-3 (KNLNTS) piezo-ceramic. Array elements were spaced at a 75-mu m pitch, and interconnected via a custom flexible circuit. The two matching layers and a light backing material were used to improve the performance of the array. The developed KNLNTS ceramic-based lead-free linear array exhibited a center frequency of 18.3 MHz, an average -6-dB bandwidth of 42%, an average two-way insertion loss of 41.8 dB, and a crosstalk between the adjacent elements of less than -53 dB near the center frequency. An image of a tungsten wire phantom was acquired using aVerasonics Vantage research ultrasound system. Results from imaging tests demonstrated a good imaging capability with a spatial resolution of 105 mu m axially and 166 mu m laterally, indicating that the lead-free linear array ultrasonic transducer based on KNLNTS ceramics is a promising alternative to lead-based transducers for ultrasound medical imaging.2019-01-31T07:12:04ZZein-Paclitaxel Prodrug Nanoparticles for Redox-Triggered Drug Delivery and Enhanced Therapeutic EfficiencyWong, Ka-hingHou, HetingZhang, DongLin, JiewenZhang, YingyingLi, ChengyongWang, ZheRen, JiaoyanYao, MaojinWang, Yihttp://www.irgrid.ac.cn:8080/handle/1471x/23403502019-05-06T01:40:48Z2019-01-31T07:12:04Z题名: Zein-Paclitaxel Prodrug Nanoparticles for Redox-Triggered Drug Delivery and Enhanced Therapeutic Efficiency
作者: Wong, Ka-hing; Hou, Heting; Zhang, Dong; Lin, Jiewen; Zhang, Yingying; Li, Chengyong; Wang, Zhe; Ren, Jiaoyan; Yao, Maojin; Wang, Yi2019-01-31T07:12:04ZEmerging roles of the neural adaptor FE65 in neurite outgrowthNgo, Jacky Chi KiLau, Kwok-FaiLi, WenChan, Wai Wa Rayhttp://www.irgrid.ac.cn:8080/handle/1471x/23403482019-05-06T01:40:48Z2019-01-31T07:12:03Z题名: Emerging roles of the neural adaptor FE65 in neurite outgrowth
作者: Ngo, Jacky Chi Ki; Lau, Kwok-Fai; Li, Wen; Chan, Wai Wa Ray2019-01-31T07:12:03ZNovel MnO2/cobalt composites nanosheets array as efficient anode for asymmetric supercapacitorHou, JuanQin, TianfengPeng, ShanglongHao, JiaxinLi, HaoqianWen, YuxiangWang, ZileiHuang, JuanjuanMa, FeiCao, Guozhonghttp://www.irgrid.ac.cn:8080/handle/1471x/23403472019-05-06T01:40:48Z2019-01-31T07:12:03Z题名: Novel MnO2/cobalt composites nanosheets array as efficient anode for asymmetric supercapacitor
作者: Hou, Juan; Qin, Tianfeng; Peng, Shanglong; Hao, Jiaxin; Li, Haoqian; Wen, Yuxiang; Wang, Zilei; Huang, Juanjuan; Ma, Fei; Cao, Guozhong
摘要: Cobalt-based composites are generally investigated as cathode for supercapacitor due to its excellent electrochemical properties. Here, we explore its application as anode with the potential window of -0.3 -0 V in 6 M KOH aqueous electrolyte. Interconnected Co3O4/CoO/Co(OH)(2) nanosheets array is one-step electrodeposited on the surface of active carbon cloth, but showing low capacitance. Surprisingly, after in-situ compositing with MnO2 (ratio of Mn4+ is similar to 23%), the hybrid MnO2/cobalt composites nanosheets array anode delivers similar to 705 F g(-1) at 0.68 A g(-1), much higher than that of similar to 161 F g(-1) for pristine Co3O4/CoO/Co(OH)(2). Besides, using NiCO2S4 nanosheet array@ nickel foam as cathode, the asymmetric supercapacitor exhibits high specific capacitance of 198 F g(-1) at the current density of 0.5 A g(-1). This work manifests a promising strategy to explore novel anode material and improve their properties, which holds great promise in energy storage/conversion devices. 2019-01-31T07:12:03ZMultidimensional Ternary Hybrids with Synergistically Enhanced Electrical Performance for Conductive Nanocomposites and Prosthetic Electronic SkinZhao, TaoWang, HuiLiang, XianwenZhou, FengruiZhu, PengliLi, GuanglinWong, Ching-PingSun, RongHu, YougenLiu, XuebinTian, Lanhttp://www.irgrid.ac.cn:8080/handle/1471x/23403492019-05-06T01:40:48Z2019-01-31T07:12:03Z题名: Multidimensional Ternary Hybrids with Synergistically Enhanced Electrical Performance for Conductive Nanocomposites and Prosthetic Electronic Skin
作者: Zhao, Tao; Wang, Hui; Liang, Xianwen; Zhou, Fengrui; Zhu, Pengli; Li, Guanglin; Wong, Ching-Ping; Sun, Rong; Hu, Yougen; Liu, Xuebin; Tian, Lan
摘要: Graphene and silver nanowires (AgNWs) are ideal fillers for conductive polymer composites, but they tend to aggregate in the polymer matrix due to the lack of surface functional groups and large specific surface area, which is hard for the polymer composites filled with them to reach their full potential. Here, ternary hybrids with multidimensional architectures including 3D polystyrene (PS) microspheres, 2D reduced graphene oxide (RGO) nanosheets, and 1D AgNWs are obtained using a simple, but effective, electrostatic attraction strategy. The electrical conductivity (136.25 S m(-1)) of the ternary hybrid conductive nanocomposites filled with RGO and AgNWs is significantly higher than that of the nanocomposites containing only RGO (3.255 S m(-1)) at the same total filler loading due to the synergistic effect of RGO and AgNWs. The conductive nanocomposites simultaneously present a low percolation threshold of 0.159 vol % and a maximum electrical conductivity of 1230 S m(-1) at 3.226 vol % filler loading. Moreover, a flexible electronic skin based on the multidimensional ternary hybrids is presented, and it exhibits large stretchability, high gauge factor, and excellent cyclic working durability, which is successfully demonstrated in monitoring prosthetic finger motions.2019-01-31T07:12:03ZIn vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administrationQu, SongnanBao, XinYuan, YeChen, JingqinZhang, BohanLi, DiZhou, DingJing, PengtaoXu, GuiyingWang, YingliHola, KaterinaShen, DezhenWu, ChangfengSong, LiangLiu, ChengboZboril, Radekhttp://www.irgrid.ac.cn:8080/handle/1471x/23403452019-05-06T01:40:48Z2019-01-31T07:12:02Z题名: In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration
作者: Qu, Songnan; Bao, Xin; Yuan, Ye; Chen, Jingqin; Zhang, Bohan; Li, Di; Zhou, Ding; Jing, Pengtao; Xu, Guiying; Wang, Yingli; Hola, Katerina; Shen, Dezhen; Wu, Changfeng; Song, Liang; Liu, Chengbo; Zboril, Radek
摘要: Carbon dots that exhibit near-infrared fluorescence (NIR CDs) are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents. Despite progress in the synthesis of NIR CDs, there remains a key obstacle to using them as an in vivo theranostic agent. This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy (PTT) in mouse models (conversion efficiency of 59%) and can be readily visualized by photoluminescence and photoacoustic imaging. The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting. Contrary to all other nanomaterials that have been tested in biomedicine, they are excreted through the body's renal filtration system. Moreover, after intravenous injection, NIR CDs are accumulated in tumor tissue via passive targeting, without any active species such as antibodies. Due to their accumulation in tumor tissue without the need for intratumor injection, high photothermal conversion, excel lent optical and photoacoustic imaging performance, and renal excretion, the developed CDs are suitable for transfer to clinical biomedical practice.2019-01-31T07:12:02Z