Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80
文献类型：期刊论文
| 作者 | Ruan, Yeping; Yao, Li; Zhang, Bingbing; Zhang, Shuijuan; Guo, Jianyou |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:7页码:1526-1529 |
| 关键词 | Neurotoxin-1 Nanoparticles Polysorbate-80 Antinociceptive properties Nasal delivery |
| ISSN号 | 0027-8424 |
| 产权排序 | 2 |
| 通讯作者 | Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China. |
| 英文摘要 | Neurotoxin-1 (NT) is an analgesic peptide which is endowed an exceptional specificity of action that blocks transmission of the nerve impulse. The aim of this study was to evaluate the potential application of nanoparticles technology as drug carrier system for the nasal delivery of NT. Mice were administered intranasally (i.n.) with NT (NT-P-NP), free NT solution (F-NT) and intravenously (i.v.) with NT (IV-NT) respectively. The NT levels in animal brain and antinociceptive activity of NT were analyzed. The result on brain transport showed that nanoparticles could exert enhanced delivery of NT into the brain significantly after i.n. administration. The results of antinociceptive activity showed that NT-P-NP increased immobility in the open-field test, both phases of formalin test were significantly inhibited by the NT-P-NP and NT-P-NP significantly inhibited the reaction time to thermal stimuli at 60 and 90 min. Both NT-P-NP and IV-NT were able to inhibit constrictions in acetic acid-induced writhing reaction. These data suggest that NT-loaded nanoparticles coated with polysorbate-80 could generate a significant improvement of drug levels in the brain. Intranasal administration of Neurotoxin1 entrapped in nanoparticles coated with polysorbate-80 is an attractive alternative to intravenous administration. (C) 2011 Elsevier Inc. All rights reserved. |
| 学科主题 | Medical psychology |
| 收录类别 | SCI |
| 项目简介 | This project was supported by Nature Sciences Foundation of Zhejiang (Y2101127). |
| 原文出处 | http://ac.els-cdn.com/S0196978111001793/1-s2.0-S0196978111001793-main.pdf?_tid=25377574-a849-11e4-9c1f-00000aacb35f&acdnat=1422599463_1a09a2e5821d766d4bbb5dfcab978d3d |
| 语种 | 英语 |
| WOS记录号 | WOS:000293679200023 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14296]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 推荐引用方式 GB/T 7714 | Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80[J]. PEPTIDES,2011,32(7):1526-1529. |
| APA | Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,&Guo, Jianyou.(2011).Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80.PEPTIDES,32(7),1526-1529. |
| MLA | Ruan, Yeping,et al."Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80".PEPTIDES 32.7(2011):1526-1529. |
入库方式： OAI收割
来源：心理研究所
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