Binding of bacterial secondary messenger molecule c di-GMP is a STING operation
文献类型：期刊论文
| 作者 | Shaw, Neil; Ouyang, Songying; Liu, Zhi-jie |
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:2页码:117-129 |
| 关键词 | innate immune response adaptor protein dimeric assembly crystal structure c di-GMP |
| ISSN号 | 1674-800X |
| 产权排序 | 2 |
| 通讯作者 | Liu, ZJ (reprint author), Chinese Acad Sci, Inst Psychol, Natl Lab Biomacromol, Beijing 100101, Peoples R China. |
| 英文摘要 | Initial skirmishes between the host and pathogen result in spillage of the contents of the bacterial cell. Amongst the spillage, the secondary messenger molecule, cyclic dimeric guanosine monophosphate (c di-GMP), was recently shown to be bound by stimulator of interferon genes (STING). Binding of c di-GMP by STING activates the Tank Binding Kinase (TBK1) mediated signaling cascades that galvanize the body's defenses for elimination of the pathogen. In addition to c di-GMP, STING has also been shown to function in innate immune responses against pathogen associated molecular patterns (PAMPs) originating from the DNA or RNA of pathogens. The pivotal role of STING in host defense is exemplified by the fact that STING(-/-) mice die upon infection by HSV-1. Thus, STING plays an essential role in innate immune responses against pathogens. This opens up an exciting possibility of targeting STING for development of adjuvant therapies to boost the immune defenses against invading microbes. Similarly, STING could be targeted for mitigating the inflammatory responses augmented by the innate immune system. This review summarizes and updates our current understanding of the role of STING in innate immune responses and discusses the future challenges in delineating the mechanism of STING-mediated responses. |
| 学科主题 | Physiological psychology/Biological Psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Natural Science Foundation of China (Grant No. 31070660) and the Ministry of Science and Technology of China (No. 2009DFB30310). |
| 原文出处 | http://zjliulab.ibp.ac.cn/zjliu-newweb/PDF/042.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000316228300004 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14312]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 推荐引用方式 GB/T 7714 | Shaw, Neil,Ouyang, Songying,Liu, Zhi-jie. Binding of bacterial secondary messenger molecule c di-GMP is a STING operation[J]. PROTEIN & CELL,2013,4(2):117-129. |
| APA | Shaw, Neil,Ouyang, Songying,&Liu, Zhi-jie.(2013).Binding of bacterial secondary messenger molecule c di-GMP is a STING operation.PROTEIN & CELL,4(2),117-129. |
| MLA | Shaw, Neil,et al."Binding of bacterial secondary messenger molecule c di-GMP is a STING operation".PROTEIN & CELL 4.2(2013):117-129. |
入库方式： OAI收割
来源：心理研究所
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