转轮运动对小鼠吗啡条件性位置偏爱的建立、消退及重建的影响
文献类型：期刊论文
| 作者 | 李敏1; 田卫平1; 曾坤1; 赵媚1
|
| 刊名 | 中国药物依赖性杂志
 |
| 出版日期 | 2012 |
| 卷号 | 21期号:2页码:111-114 |
| 通讯作者邮箱 | zhaomei@psych.ac.cn |
| 关键词 | 吗啡 条件位置性偏爱 消退 重建 点燃 转轮运动 |
| ISSN号 | 1007-9718 |
| 其他题名 | THE EFFECT OF RUNNING -WHEEL ON THE ESTABLISHMENT, EXTINCTION AND REINSTATEMENT OF MORPHINE CONDITIONED PLACE PREFERENCE IN MICE |
| 产权排序 | 3 |
| 通讯作者 | 赵媚 |
| 中文摘要 | 目的:研究转轮运动对小鼠吗啡条件性位置偏爱(conditioned place preference,CPP)的建立、消退及重建的影响。方法:每次吗啡CPP训练之后,均将动物置于特制的带有转轮的饲养笼内6 h;在CPP测试之后,动物每天在训练箱中自由穿梭,进行CPP消退训练;待CPP消退之后,皮下注射(sc)10 mg.kg-1吗啡点燃。结果:非转轮运动组和转轮运动组的小鼠经过吗啡CPP训练后,在伴药箱的时间较训练前均显著增加(P0.05)。sc吗啡点燃后,非转轮运动组CPP能够重建,而转轮运动组CPP未能重建;结论:转轮运动对吗啡CPP的建立及消退均没有影响,但可以抑制吗啡CPP的重建。 |
| 英文摘要 | Objective： To detect the effects of running - wheel on the establishment, extinction and reinstatement of morphine CPP in mice. Methods： The animals were put into the special cages with running - wheel apparatus 6 h after morphine CPP training. After the post - conditioning test of CPP, the mice were trained for extinction of morphine CPP by allowing the animals to run cross the CPP chambers freely. Subcutaneous injection of morphine（ 10 mg · kg^-1） was used to reinstate the morphine CPP after its extinction. Results：After morphine CPP training, the time spent in the morphine - paired chamber increased significantly in both running - wheel group and non - running - wheel group compared with that in the pre-conditioning test（P 〈0. 001）, but there was no significant difference between the two groups（P 〉 0.05）. In addition, there was no difference between the two groups at extinction training stage （P 〉 0. 05）. However,the extinguished CPP could be reinstated in non- running- wheel group, but not in running- wheel group in priming test. Conclusion.： Running -wheel inhibited the reinstatement of morphine CPP ,whereas had no effects on the establishment and extinction of morphine -induced CPP. KEY WORDS |
| 学科主题 | 生理心理学/生物心理学 |
| 收录类别 | CSCD |
| 原文出处 | http://159.226.100.28/qk/98337A/201202/41690328.html |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4521378 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15163]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.温州医学院基因组医学研究院,温州,325000 2.西安交通大学医学院法医系,西安,710061 3.中国科学院心理研究所心理健康重点实验室,北京,100101 |
| 推荐引用方式 GB/T 7714 | 李敏,田卫平,曾坤,等. 转轮运动对小鼠吗啡条件性位置偏爱的建立、消退及重建的影响[J]. 中国药物依赖性杂志,2012,21(2):111-114. |
| APA | 李敏,田卫平,曾坤,&赵媚.(2012).转轮运动对小鼠吗啡条件性位置偏爱的建立、消退及重建的影响.中国药物依赖性杂志,21(2),111-114. |
| MLA | 李敏,et al."转轮运动对小鼠吗啡条件性位置偏爱的建立、消退及重建的影响".中国药物依赖性杂志 21.2(2012):111-114. |
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来源：心理研究所
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