Behavioral and pharmacological investigation of anxiety and maternal responsiveness of postpartum female rats in a pup elevated plus maze
文献类型：期刊论文
| 作者 | Yang, Yu1,2; Qin, Jingxue1,2; Chen, Weihai1,2; Sui, Nan3 ; Chen, Hong1,2; Li, Ming4
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| 刊名 | BEHAVIOURAL BRAIN RESEARCH
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| 出版日期 | 2015-10-01 |
| 卷号 | 292期号:0页码:414-427 |
| 关键词 | Postpartum anxiety Maternal responsiveness Elevated plus maze Haloperidol Fluoxetine Diazepam |
| ISSN号 | 0166-4328 |
| 英文摘要 | The present study investigated the validity of a novel pup-based repeated elevated plus maze task to detect reduced anxiety and increased maternal responsiveness in postpartum female rats and explored the roles of dopamine D-2, serotonin transporter and GABA/benzodiazepine receptors in the mediation of these processes. Sprague-Dawley postpartum or nulliparous female rats were tested 4 times every other day on postpartum days 4,6 and 8 in an elevated plus maze with 4 pups or 4 pup-size erasers placed on each end of the two open arms. When tested with erasers, untreated postpartum mother rats entered the open arms proportionally more than nulliparous rats. They also tended to spend more time in the open arms, indicating reduced anxiety. When tested with pups, postpartum rats retrieved pups into the closed arms, entered the open arms and closed arms more and had a higher moving speed than nulliparous rats, indicating increased maternal responsiveness. Both haloperidol (0.1 or 0.2 mg/kg, sc) and fluoxetine (5 or 10 mg/kg, ip) dose- and time-dependently decreased the percentage of time spent in the open arms and speed, but did not affect the percentage of open arm entries. Diazepam (1.0 or 2.0 mg/kg, ip) did not affect pup retrieval, open arm time/entry in lactating rats. Thus, the percentage of open arm entries appears to be the most sensitive measure of anxiety in postpartum female rats, while speed could be used to index maternal responsiveness to pups, which are likely mediated by the dopamine D-2 and serotonin transporter systems. (C) 2015 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361583500048 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15218]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing 400715, Peoples R China 2.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA |
| 推荐引用方式 GB/T 7714 | Yang, Yu,Qin, Jingxue,Chen, Weihai,et al. Behavioral and pharmacological investigation of anxiety and maternal responsiveness of postpartum female rats in a pup elevated plus maze[J]. BEHAVIOURAL BRAIN RESEARCH,2015,292(0):414-427. |
| APA | Yang, Yu,Qin, Jingxue,Chen, Weihai,Sui, Nan,Chen, Hong,&Li, Ming.(2015).Behavioral and pharmacological investigation of anxiety and maternal responsiveness of postpartum female rats in a pup elevated plus maze.BEHAVIOURAL BRAIN RESEARCH,292(0),414-427. |
| MLA | Yang, Yu,et al."Behavioral and pharmacological investigation of anxiety and maternal responsiveness of postpartum female rats in a pup elevated plus maze".BEHAVIOURAL BRAIN RESEARCH 292.0(2015):414-427. |
入库方式： OAI收割
来源：心理研究所
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