Spontaneous Activity in the Precuneus Predicts Individual Differences in Verbal Fluency in Cognitively Normal Elderly
文献类型：期刊论文
| 作者 | Yin, Shufei1; Zhu, Xinyi1 ; He, Rongqiao2; Li, Rui1; Li, Juan1,3
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| 刊名 | NEUROPSYCHOLOGY
 |
| 出版日期 | 2015-11-01 |
| 卷号 | 29期号:6页码:961-970 |
| 关键词 | verbal fluency precuneus spontaneous activity resting-state fMRI elderly |
| ISSN号 | 0894-4105 |
| 英文摘要 | Objective: The precuneus is 1 of the major cortical hubs and plays an important role in normal aging and verbal fluency processing. The main aim of present study was to investigate how intrinsic brain activity in the precuneus at rest predicts individual differences in verbal fluency ability among elderly adults. Method: Regional amplitude of low-frequency fluctuations (ALFF) analysis and a correlation-based functional connectivity (FC) approach were used to analyze data acquired from 101 cognitively normal elderly. Results: ALFF in the precuneus declined with normal aging and was significantly correlated with individual differences in performance on the verbal fluency test (VFT). Specifically, ALFF in the precuneus was reduced in elderly with high fluency (HF) ability compared with those with low fluency (LF) ability. In addition, the HF individuals displayed increased functional connectivity of the precuneus with the lateral temporal area and prefrontal lobe, including the inferior frontal, medial frontal, superior temporal, middle temporal, and superior frontal gyri. Conclusion: Spontaneous activity in the precuneus could predict individual differences in verbal fluency processing. Our results suggest that spontaneous activity in the precuneus is an indicator of aging-related changes in semantic verbal fluency processing, or even a potential biomarker for the early detection of semantic verbal fluency deterioration. |
| 收录类别 | SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364592100016 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15321]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 心理研究所_健康与遗传心理学研究室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Shufei,Zhu, Xinyi,He, Rongqiao,et al. Spontaneous Activity in the Precuneus Predicts Individual Differences in Verbal Fluency in Cognitively Normal Elderly[J]. NEUROPSYCHOLOGY,2015,29(6):961-970. |
| APA | Yin, Shufei,Zhu, Xinyi,He, Rongqiao,Li, Rui,&Li, Juan.(2015).Spontaneous Activity in the Precuneus Predicts Individual Differences in Verbal Fluency in Cognitively Normal Elderly.NEUROPSYCHOLOGY,29(6),961-970. |
| MLA | Yin, Shufei,et al."Spontaneous Activity in the Precuneus Predicts Individual Differences in Verbal Fluency in Cognitively Normal Elderly".NEUROPSYCHOLOGY 29.6(2015):961-970. |
入库方式： OAI收割
来源：心理研究所
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