Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization
文献类型：期刊论文
| 作者 | Jiang, Lili1,2 ; Xu, Ting1,2; He, Ye1,2,3; Hou, Xiao-Hui1,2,3; Wang, Jinhui4,5; Cao, Xiao-Yan1,2,4,5; Wei, Gao-Xia1,2; Yang, Zhi1,2; He, Yong6,7,8; Zuo, Xi-Nian1,2,8
|
| 刊名 | BRAIN STRUCTURE & FUNCTION
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 220期号:5页码:2485-2507 |
| 关键词 | Functional homogeneity Prefrontal cortex Posteromedial cortex Functional hierarchy Structural morphometry Functional covariance Network |
| ISSN号 | 1863-2653 |
| 英文摘要 | Local functional homogeneity of the human cortex indicates the boundaries between functionally heterogeneous regions and varies remarkably across the cortical mantle. It is unclear whether these variations have the neurobiological and structural basis. We employed structural and resting-state functional magnetic resonance imaging scans from 482 healthy subjects and computed the vertex-wise regional homogeneity of low-frequency fluctuations (2dReHo) and five measures of cortical morphology. We then used these metrics to examine regional variation, morphological association and functional covariance network of 2dReHo. Within the ventral visual stream, increases of 2dReHo reflect reduced complexity of information processing or functional hierarchies. Along the divisions of the prefrontal cortex and posteromedial cortex, the gradients of 2dReHo revealed the hierarchical organization within the two association areas, respectively. Individual differences in 2dReHo are associated with those of cortical morphology, and their whole-brain inter-regional covariation is organized into a functional covariance network, comprising five hierarchically organized modules with hubs of both primary sensory and high-order association areas. These highly reproducible observations suggest that local functional homogeneity has neurobiological relevance that is likely determined by anatomical, developmental and neurocognitive factors and should serve as a neuroimaging marker to investigate the human brain function. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360069200002 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15237]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Lab Funct Connectome & Dev, Key Lab Behav Sci, Inst Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou 310036, Zhejiang, Peoples R China 5.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou 310036, Zhejiang, Peoples R China 6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100087, Peoples R China 7.Beijing Normal Univ, Int Data Grp, McGovern Inst Brain Res, Beijing 100087, Peoples R China 8.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100087, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Lili,Xu, Ting,He, Ye,et al. Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization[J]. BRAIN STRUCTURE & FUNCTION,2015,220(5):2485-2507. |
| APA | Jiang, Lili.,Xu, Ting.,He, Ye.,Hou, Xiao-Hui.,Wang, Jinhui.,...&Zuo, Xi-Nian.(2015).Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization.BRAIN STRUCTURE & FUNCTION,220(5),2485-2507. |
| MLA | Jiang, Lili,et al."Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization".BRAIN STRUCTURE & FUNCTION 220.5(2015):2485-2507. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。