Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng
文献类型：期刊论文
| 作者 | Gu, Cheng-Zhen; Lv, Jun-Jiang; Zhang, Xiao-Xia; Yan, Hui; Zhu, Hong-Tao; Luo, Huai-Rong ; Wang, Dong; Yang, Chong-Ren; Xu, Min; Zhang, Ying-Jun
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 103页码:97-105 |
| 关键词 | Panax notoginseng Triterpenoid saponins PC12 cells |
| 英文摘要 | Nine new minor dehydrogenated and cleavaged dammarane-type triterpenoid saponins, namely notoginsenosides ST6-ST14 (1-9) were isolated from the steamed roots of Panax notoginseng, together with 14 known ones. Among them, 5-7 and 21-22 were protopanaxadiol type and the left 18 compounds, including 1-4, 8-20, and 23 were protopanaxatriol type saponins. Their structures were identified by extensive analysis of MS, 1D and 2D NMR spectra, and acidic hydrolysis. Resulted from the side chain cleavage, the new saponins 1 and 2 featured in a ketone group at C-25, and 3-5 had an aldehyde unit at C-23. The known saponins 12,16 and 18 displayed the enhancing potential of neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 mu M, while 20 exhibited acetyl cholinesterase inhibitory activity, with IC50 value of 13.97 mu M. (C) 2015 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | MICROBIAL TRANSFORMATION ; FLOWER-BUDS ; IN-VITRO ; GINSENG ; GLYCOSIDES ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356738800011 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/24966]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gu, Cheng-Zhen,Lv, Jun-Jiang,Zhang, Xiao-Xia,et al. Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng[J]. FITOTERAPIA,2015,103:97-105. |
| APA | Gu, Cheng-Zhen.,Lv, Jun-Jiang.,Zhang, Xiao-Xia.,Yan, Hui.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2015).Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng.FITOTERAPIA,103,97-105. |
| MLA | Gu, Cheng-Zhen,et al."Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng".FITOTERAPIA 103(2015):97-105. |
入库方式： OAI收割
来源：昆明植物研究所
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