Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis
文献类型：期刊论文
| 作者 | Xue, Yongbo; Li, Xifeng; Du, Xue; Li, Xiaonian; Wang, Weiguang; Yang, Jianhong; Chen, Jijun ; Pu, Jianxin; Sun, Handong
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2015-08-01 |
| 卷号 | 116页码:253-261 |
| 关键词 | Schisandra chinensis Schisandraceae Dibenzocyclooctadiene lignans 6,7-Seco-homolignan Hepatitis B virus |
| 英文摘要 | Seven lignans with a dibenzocyclooctadiene skeleton, termed schinlignans A-G, and a 6,7-seco-homolignan, schischinone, together with seven known lignans, were isolated from the fruits of Schisandra chinensis (Turcz.) Baill. Their structures were elucidated by extensive spectroscopic methods, including HRESIMS, IR, UV, and 2D NMR (COSY, HMQC, COSY, and HMBC experiments). The stereochemistry at the chiral centers and the biphenyl moiety, were determined using ROESY, as well as via interpretation of their ECD spectra. Schinlignan G and methylgomisin O exhibited potent anti-hepatitis B virus activity against HBV DNA replication with IC50 values of 5.13 and 5.49 mu g mL(-1), respectively. (C) 2015 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | HIGHLY OXYGENATED NORTRITERPENOIDS ; ABSOLUTE STRUCTURE ; GOMISIN-A ; CONSTITUENTS ; BAILL ; SPHENANTHERA ; SCHIZANDRIN ; LEAVES ; STEMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000357438200028 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/24977]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xue, Yongbo,Li, Xifeng,Du, Xue,et al. Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis[J]. PHYTOCHEMISTRY,2015,116:253-261. |
| APA | Xue, Yongbo.,Li, Xifeng.,Du, Xue.,Li, Xiaonian.,Wang, Weiguang.,...&Sun, Handong.(2015).Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis.PHYTOCHEMISTRY,116,253-261. |
| MLA | Xue, Yongbo,et al."Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis".PHYTOCHEMISTRY 116(2015):253-261. |
入库方式： OAI收割
来源：昆明植物研究所
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