Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects
文献类型：期刊论文
| 作者 | Yang, Da-Song; Li, Zi-Lei; Peng, Wei-Bing; Yang, Yong-Ping ; Wang, Xue; Liu, Ke-Chun; Li, Xiao-Li; Xiao, Wei-Lie
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 103页码:165-170 |
| 关键词 | Macaranga denticulata Euphorbiaceae Flavonoid-diterpene heterodimer Geranylated flavonoids Anticancer effects |
| 英文摘要 | One rare flavonoid-diterpene heterodimer, denticulatain C (1), one modified geranyl-type side chain substituted flavonoid, denticulatain D (2) and one geranylated flavonoid, denticulatain E (3), as well as 11 known compounds (4-14) were isolated from the fronds of Macaranga denticulate. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 4 and 8 inhibited the proliferation of A-549 cell line with IC50 values of 48.6 and 20.2 mu g/mL, respectively. Compounds 3, 6, and 8 exhibited significant antiangiogenic activity on a zebrafish model with IC50 values of 9.78, 034, and 2.55 mu g/mL, respectively. (C) 2015 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | BROUSSONETIA-PAPYRIFERA ; CHEMICAL-CONSTITUENTS ; INHIBITORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356738800020 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/24964]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang, Da-Song,Li, Zi-Lei,Peng, Wei-Bing,et al. Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects[J]. FITOTERAPIA,2015,103:165-170. |
| APA | Yang, Da-Song.,Li, Zi-Lei.,Peng, Wei-Bing.,Yang, Yong-Ping.,Wang, Xue.,...&Xiao, Wei-Lie.(2015).Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects.FITOTERAPIA,103,165-170. |
| MLA | Yang, Da-Song,et al."Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects".FITOTERAPIA 103(2015):165-170. |
入库方式： OAI收割
来源：昆明植物研究所
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