The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions
文献类型：期刊论文
| 作者 | Xuan, Jinsong1; Feng, Yingang2,3
|
| 刊名 | CURRENT PROTEIN & PEPTIDE SCIENCE
 |
| 出版日期 | 2012-05-01 |
| 卷号 | 13期号:3页码:258-266 |
| 关键词 | Archaea Sac10b protein family X-ray and NMR structures DNA- and RNA-binding proteins functional diversity |
| 英文摘要 | Here we review the present state of structural and functional studies of the Sac10b protein family, a class of highly conserved 10 kDa nucleic acid-binding proteins in archaea. Based on biochemical and structural studies, these proteins were originally assigned a role in the structural organization of chromatin; Sac10b proteins of hyperthermophilic archaea, for example, showed tight, unspecific DNA binding. More recently, however, Sac10b proteins of mesophilic archaea were found to interact preferentially with specific DNA sequences thereby affecting the expression of distinct genes. Furthermore, Sac10b proteins of hyperthermophilic, thermophilic and mesophilic archaea were also shown to bind to RNA with distinct affinities and specificities but functional consequences of RNA binding of these proteins, besides perhaps RNA stabilization, have not yet been observed. To better understand the physiological meaning of the various interactions of Sac10b proteins with nucleic acids, future work should concentrate on elucidating the molecular structures of complexes of Sac10b proteins of hyperthermophilic and mesophilic archaea with DNA and RNA. In addition, existing and new X-ray and NMR structures of individual hyperthermophilic Sac10b proteins may represent very good models for introducing thermostability especially in enzymes for industrial use. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | DNA-BINDING PROTEIN ; ARCHAEBACTERIUM SULFOLOBUS-ACIDOCALDARIUS ; NUCLEIC-ACID BINDING ; CHROMATIN PROTEIN ; CRYSTAL-STRUCTURE ; HYPERTHERMOPHILIC ARCHAEAL ; MICROSEQUENCE ANALYSIS ; METHANOCOCCUS-VOLTAE ; ALBA ; STABILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304597300006 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/6334]  |
| 专题 | 青岛生物能源与过程研究所_代谢物组学团队 |
| 作者单位 | 1.Univ Sci & Technol Beijing, Dept Biol Sci & Engn, Sch Chem & Biol Engn, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xuan, Jinsong,Feng, Yingang. The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2012,13(3):258-266. |
| APA | Xuan, Jinsong,&Feng, Yingang.(2012).The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions.CURRENT PROTEIN & PEPTIDE SCIENCE,13(3),258-266. |
| MLA | Xuan, Jinsong,et al."The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions".CURRENT PROTEIN & PEPTIDE SCIENCE 13.3(2012):258-266. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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