Genome-wide identification of transcription factors and transcription-factor binding sites in oleaginous microalgae Nannochloropsis
文献类型：期刊论文
| 作者 | Hu, Jianqiang1,2; Wang, Dongmei1 ; Li, Jing1,2; Jing, Gongchao1; Ning, Kang1; Xu, Jian1
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2014-06-26 |
| 卷号 | 4 |
| 英文摘要 | Nannochloropsis spp. are a group of oleaginous microalgae that harbor an expanded array of lipid-synthesis related genes, yet how they are transcriptionally regulated remains unknown. Here a phylogenomic approach was employed to identify and functionally annotate the transcriptional factors (TFs) and TF binding-sites (TFBSs) in N. oceanica IMET1. Among 36 microalgae and higher plants genomes, a two-fold reduction in the number of TF families plus a seven-fold decrease of average family-size in Nannochloropsis, Rhodophyta and Chlorophyta were observed. The degree of similarity in TF-family profiles is indicative of the phylogenetic relationship among the species, suggesting co-evolution of TF-family profiles and species. Furthermore, comparative analysis of six Nannochloropsis genomes revealed 68 "most-conserved" TFBS motifs, with 11 of which predicted to be related to lipid accumulation or photosynthesis. Mapping the IMET1 TFs and TFBS motifs to the reference plant TF-"TFBS motif" relationships in TRANSFAC enabled the prediction of 78 TF-"TFBS motif" interaction pairs, which consisted of 34 TFs (with 11 TFs potentially involved in the TAG biosynthesis pathway), 30 TFBS motifs and 2,368 regulatory connections between TFs and target genes. Our results form the basis of further experiments to validate and engineer the regulatory network of Nannochloropsis spp. for enhanced biofuel production. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | REGULATORY ELEMENTS ; CHLAMYDOMONAS-REINHARDTII ; ESCHERICHIA-COLI ; GENE-REGULATION ; ARABIDOPSIS ; DATABASE ; DISCOVERY ; EVOLUTION ; SEQUENCE ; PREDICTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337892000003 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/6304]  |
| 专题 | 青岛生物能源与过程研究所_单细胞中心 |
| 作者单位 | 1.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Single Cell Ctr, CAS Key Lab Biofuels & Shandong Key Lab Energy Ge, Qingdao 266101, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Jianqiang,Wang, Dongmei,Li, Jing,et al. Genome-wide identification of transcription factors and transcription-factor binding sites in oleaginous microalgae Nannochloropsis[J]. SCIENTIFIC REPORTS,2014,4. |
| APA | Hu, Jianqiang,Wang, Dongmei,Li, Jing,Jing, Gongchao,Ning, Kang,&Xu, Jian.(2014).Genome-wide identification of transcription factors and transcription-factor binding sites in oleaginous microalgae Nannochloropsis.SCIENTIFIC REPORTS,4. |
| MLA | Hu, Jianqiang,et al."Genome-wide identification of transcription factors and transcription-factor binding sites in oleaginous microalgae Nannochloropsis".SCIENTIFIC REPORTS 4(2014). |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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