The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration
文献类型：期刊论文
| 作者 | Liang, Jin1,2,3; Wang, Dongmei4 ; Renaud, Gabriel1,2; Wolfsberg, Tyra G.1,2; Wilson, Alexander F.; Burgess, Shawn M.1,2
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2012-08-01 |
| 卷号 | 32期号:31页码:10662-10673 |
| 英文摘要 | All nonmammalian vertebrates studied can regenerate inner ear mechanosensory receptors (i.e., hair cells) (Corwin and Cotanche, 1988; Lombarte et al., 1993; Baird et al., 1996), but mammals possess only a very limited capacity for regeneration after birth (Roberson and Rubel, 1994). As a result, mammals experience permanent deficiencies in hearing and balance once their inner ear hair cells are lost. The mechanisms of hair cell regeneration are poorly understood. Because the inner ear sensory epithelium is highly conserved in all vertebrates (Fritzsch et al., 2007), we chose to study hair cell regeneration mechanism in adult zebrafish, hoping the results would be transferrable to inducing hair cell regeneration in mammals. We defined the comprehensive network of genes involved in hair cell regeneration in the inner ear of adult zebrafish with the powerful transcriptional profiling technique digital gene expression, which leverages the power of next-generation sequencing ('t Hoen et al., 2008). We also identified a key pathway, stat3/socs3, and demonstrated its role in promoting hair cell regeneration through stem cell activation, cell division, and differentiation. In addition, transient pharmacological inhibition of stat3 signaling accelerated hair cell regeneration without overproducing cells. Taking other published datasets into account (Sano et al., 1999; Schebesta et al., 2006; Dierssen et al., 2008; Riehle et al., 2008; Zhu et al., 2008; Qin et al., 2009), we propose that the stat3/socs3 pathway is a key response in all tissue regeneration and thus an important therapeutic target for a broad application in tissue repair and injury healing. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | LATERAL-LINE SYSTEM ; INNER-EAR ; LIVER-REGENERATION ; DANIO-RERIO ; SERINE PHOSPHORYLATION ; SIGNAL TRANSDUCER ; COCHLEAR CHANGES ; ACOUSTIC TRAUMA ; LASER-ABLATION ; HEARING-LOSS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307125900023 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/6349]  |
| 专题 | 青岛生物能源与过程研究所_单细胞中心 |
| 作者单位 | 1.NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA 2.NHGRI, Inherited Dis Res Branch, Bethesda, MD 20892 USA 3.Univ Maryland, Neurosci & Cognit Sci Program, College Pk, MD 20742 USA 4.Chinese Acad Sci, Qingdao Inst BioEnergy & BioProcess Technol, Qingdao 266101, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Jin,Wang, Dongmei,Renaud, Gabriel,et al. The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration[J]. JOURNAL OF NEUROSCIENCE,2012,32(31):10662-10673. |
| APA | Liang, Jin,Wang, Dongmei,Renaud, Gabriel,Wolfsberg, Tyra G.,Wilson, Alexander F.,&Burgess, Shawn M..(2012).The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration.JOURNAL OF NEUROSCIENCE,32(31),10662-10673. |
| MLA | Liang, Jin,et al."The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration".JOURNAL OF NEUROSCIENCE 32.31(2012):10662-10673. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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