Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives
文献类型：期刊论文
| 作者 | Zhang, Ke-jun1,2; Liu, Wu-yi1 |
| 刊名 | INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
 |
| 出版日期 | 2011-05-01 |
| 卷号 | 6期号:5页码:1669-1678 |
| 关键词 | DNA anti-carcinogen derivative of 5-Fluorouracil intercalation cyclic voltammetry |
| 英文摘要 | Although many 5-Fluorouracil derivatives have been synthesized and identified, there are few reports on the interaction modes of different anti-carcinogen 5-Fluorouracil derivatives with Deoxyribonucleic acid (DNA). In this study, five new anti-carcinogen 5-Fluorouracil derivatives with DNA were investigated, i.e. 5-FU-Asp, 5-Fu-Trp, 5-FU-Ser, 5-FU-Tyr, and 5-FU-Phe, and their DNA binding specificities were compared by electrochemical means with previous reported DNA ligands. Meanwhile, the cyclic voltammetry has been proved to be powerful for the elucidation of interactions between DNA and 5-Fluorouracil derivatives, with Fe(CN)(6)(3-/4-) as electroactive indicator of the intercalative interaction dominance. Using this electrochemical approach and Deoxyribonucleic acid (DNA) modified gold electrodes prepared by the dry adsorptive method, the electrochemical behaviors and modes of 5-Fluorouracil derivatives targeting DNA were well studied. The binding of 5-Fluorouracil derivatives with DNA, analyzed in terms of the cooperative Hill model, yields different association constants and binding numbers. This study serves as a good reference for synthesis, structural characterization of novel 5-Fluorouracil derivatives. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Electrochemistry |
| 研究领域[WOS] | Electrochemistry |
| 关键词[WOS] | CRYSTAL-STRUCTURE ; OLIGONUCLEOTIDES ; LANTHANIDES ; SEPARATION ; ACTINIDES ; COMPLEX ; CHAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290097000034 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/6546]  |
| 专题 | 青岛生物能源与过程研究所_仿生能源与储能系统团队 |
| 作者单位 | 1.Fuyang Normal Coll, Dept Biol Sci, Fuyang City 236041, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ke-jun,Liu, Wu-yi. Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives[J]. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE,2011,6(5):1669-1678. |
| APA | Zhang, Ke-jun,&Liu, Wu-yi.(2011).Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives.INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE,6(5),1669-1678. |
| MLA | Zhang, Ke-jun,et al."Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives".INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 6.5(2011):1669-1678. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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