Simultaneous quantitation of seven alkaloids in processed Fuzi decoction by rapid resolution liquid chromatography coupled with tandem mass spectrometry
文献类型：期刊论文
| 作者 | Guo, Na1; Yang, Dawei2; Ablajan, Keyume3; Niu, Xiaohong1; Fan, Bin1; Wang, Zhiguo1; Dai, Jingang1; Wu, Xiaoxia1; Liu, Baidong1 |
| 刊名 | JOURNAL OF SEPARATION SCIENCE
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 36期号:12页码:1953-1958 |
| 关键词 | Aconitum alkaloids Baifupian Fuzi Heishunpian Rapid resolution LC |
| 英文摘要 | A rapid analytical method based on rapid resolution LC coupled with MS/MS was first established to quantify seven alkaloids in processed Fuzi decoction. The chromatographic method was optimized to allow simultaneous analysis of all analytes in 5 min and demonstrated good linearity (r > 0.9995), repeatability (RSD < 4.36%), intra- and interday precisions (RSD < 5.07%) with good accuracies (97.76-105.08%) and good recovery (95.0-107.5%) of seven alkaloids, namely higenamine, benzoylhypaconine, benzoylmesaconine, benzoylaconine, aconitine, hypaconitine, and mesaconitine. The LODs for these markers were in the range of 2.30-17.00 pg/mL. Quantitative analysis of the seven alkaloids in Baifupian decoction and Heishunpian decoction showed that the content of the seven marker chemicals varied significantly and concluded that the quality of Fuzi was greatly affected by different processed methods. The developed method could be used as a rapid, sensitive, and reliable approach for assessment of the quality of processed Fuzi and related decoction. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Analytical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ACONITUM ALKALOIDS ; DITERPENOID ALKALOIDS ; MEDICINE FUZI ; CHINESE ; PHARMACOKINETICS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320553800011 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/6051]  |
| 专题 | 青岛生物能源与过程研究所_生物制氢与沼气团队 |
| 作者单位 | 1.China Acad Chinese Med Sci, Expt Res Ctr, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuel, Qingdao, Peoples R China 3.Xinjiang Univ, Coll Chem & Chem Engn, Urumqi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Na,Yang, Dawei,Ablajan, Keyume,et al. Simultaneous quantitation of seven alkaloids in processed Fuzi decoction by rapid resolution liquid chromatography coupled with tandem mass spectrometry[J]. JOURNAL OF SEPARATION SCIENCE,2013,36(12):1953-1958. |
| APA | Guo, Na.,Yang, Dawei.,Ablajan, Keyume.,Niu, Xiaohong.,Fan, Bin.,...&Liu, Baidong.(2013).Simultaneous quantitation of seven alkaloids in processed Fuzi decoction by rapid resolution liquid chromatography coupled with tandem mass spectrometry.JOURNAL OF SEPARATION SCIENCE,36(12),1953-1958. |
| MLA | Guo, Na,et al."Simultaneous quantitation of seven alkaloids in processed Fuzi decoction by rapid resolution liquid chromatography coupled with tandem mass spectrometry".JOURNAL OF SEPARATION SCIENCE 36.12(2013):1953-1958. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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