Determination of atenolol in human plasma by pseudo reversed phase liquid chromatography-tandem mass spectrometry
文献类型：期刊论文
| 作者 | Dong, Lili; Huang, Junxiong |
| 刊名 | CHROMATOGRAPHIA
 |
| 出版日期 | 2006 |
| 卷号 | 64期号:2015-09-10页码:583-586 |
| 关键词 | column liquid chromatography pseudo-RPLC MS-MS bare silica as stationary phase atenolol |
| 英文摘要 | Previous HPLC determination of atenolol on reversed-phase packings has often required a mobile phase containing three components: organic modifier, buffer and ion-pairing reagent or organic amine. In addition to the complexity of the eluents employed, alkyl sulphonates and organic amines in the mobile phase can reduce the life of silica-based bonded columns. A new simple, rapid and sensitive method-pseudo reversed-phase liquid chromatography/tandem mass spectrometry has been developed for the analysis of atenolol in human plasma using bare silica as the stationary phase coupled with a simple mobile phase consisted of 5% acetonitrile and 95% formate buffer. The optimization of separation is fast and easy. The assay was validated for the concentration range 1-100 ng mL(-1) with a detection limit of 1 ng mL(-1). Moreover, the silica column was durable with the mainly aqueous eluents. No obvious loss in performance was observed for 30,000 column volumes of eluent. |
| WOS记录号 | WOS:000242425600015 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22854]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Dong, Lili,Huang, Junxiong. Determination of atenolol in human plasma by pseudo reversed phase liquid chromatography-tandem mass spectrometry[J]. CHROMATOGRAPHIA,2006,64(2015-09-10):583-586. |
| APA | Dong, Lili,&Huang, Junxiong.(2006).Determination of atenolol in human plasma by pseudo reversed phase liquid chromatography-tandem mass spectrometry.CHROMATOGRAPHIA,64(2015-09-10),583-586. |
| MLA | Dong, Lili,et al."Determination of atenolol in human plasma by pseudo reversed phase liquid chromatography-tandem mass spectrometry".CHROMATOGRAPHIA 64.2015-09-10(2006):583-586. |
入库方式： OAI收割
来源：生态环境研究中心
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