Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phytoestrogens
文献类型：期刊论文
| 作者 | Cong, L; Qin, ZF; Jing, XN; Yang, L; Zhou, JM; Xu, XB |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 77期号:3页码:250-256 |
| 关键词 | Xenopus laevis reproductive toxicity phytoestrogen quercetin feminization |
| 英文摘要 | This study investigated effects of phytoestrogen quercetin on the gonadal development in Xenopus laevis. X. laevis at Nieuwkoop and Faber stage 46/47 were exposed to 50, 100 and 200 mu g/L quercetin till 1 month postmetamorphosis. Gonads from frogs at 1 and 3 months postmetamorphosis were examined in gross morphology and histology. The highest dose of quercetin as well as estradiol (E-2) significantly increased the percentages of phenotypic females. Exposure to quercetin at all doses induced abnormal testes with certain ovarian characteristics to some degree in gross morphology, including ovotestes. The abnormality rate exceeded 10% in each quercetin treatment. Histologic examination revealed that some abnormal testes exhibited intersexuality with testicular structure and ovarian structure or oocytes interspersed in testicular structure at 1 month postmetamorphosis. At 3 months postmetamorphosis, testicular abnormalities were more obvious, such as necrosis or apoptosis of spermatogonia, occurrence of developed or undeveloped oocytes, delay of the development of seminiferous tubes without or less late stage spermatocytes. The results have shown that quercetin cannot only feminize but also impair testicular development of X. laevis, i.e. X. laevis is sensitive to phytoestrogen. It is suggested that X. laevis might be an alternative model species to study reproductive toxicity of phytoestrogens. (c) 2006 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000237602600002 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22938]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Cong, L,Qin, ZF,Jing, XN,et al. Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phytoestrogens[J]. AQUATIC TOXICOLOGY,2006,77(3):250-256. |
| APA | Cong, L,Qin, ZF,Jing, XN,Yang, L,Zhou, JM,&Xu, XB.(2006).Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phytoestrogens.AQUATIC TOXICOLOGY,77(3),250-256. |
| MLA | Cong, L,et al."Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phytoestrogens".AQUATIC TOXICOLOGY 77.3(2006):250-256. |
入库方式： OAI收割
来源：生态环境研究中心
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