Determination of epirubicin and its impurities in pharmaceutical by hydrophilic interaction chromatography
文献类型：期刊论文
| 作者 | Li, RP; Dong, LL; Huang, JX |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2005 |
| 卷号 | 33期号:6页码:814-816 |
| 关键词 | hydrophilic interaction chromatography silica column epirubicin |
| 英文摘要 | A novel method for the determination of epirubicin by hydrophilic interaction chromatography (HILIC) using high purity silica column with highly polar organic-aqueous buffer as mobile phase has been developed. The buffer pH and concentration in the mobile phase as well as the flow rate have been optimized. The optimal mobile phase is 90% ( V/V) acetonitrile in 40 mmol/L formate buffer (pH 2.9). The flow rate was 1.0 mL/min. The system suitability has been tested under the optimal chromatographic condition, and the results show that the resolutions between the adjacent components and the asymmetry factors of the solutes meet the pharmacopoeia requirements. The proposed method has good linearity ( r = 0.9971-0.9991) and reproducibility (RSD < 1.0 % for the peak area). It has been proved simple and convenient, and applied in the determination of epirubicin and its impurities in epirubicin raw product with satisfactory results. |
| 学科主题 | Chemistry |
| 研究领域[WOS] | Chemistry |
| WOS记录号 | WOS:000230362500018 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23162]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, RP,Dong, LL,Huang, JX. Determination of epirubicin and its impurities in pharmaceutical by hydrophilic interaction chromatography[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2005,33(6):814-816. |
| APA | Li, RP,Dong, LL,&Huang, JX.(2005).Determination of epirubicin and its impurities in pharmaceutical by hydrophilic interaction chromatography.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,33(6),814-816. |
| MLA | Li, RP,et al."Determination of epirubicin and its impurities in pharmaceutical by hydrophilic interaction chromatography".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 33.6(2005):814-816. |
入库方式： OAI收割
来源：生态环境研究中心
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