Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors
文献类型：期刊论文
| 作者 | Gu, GF; Du, YG; Linhardt, RJ |
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2004 |
| 卷号 | 69期号:16页码:5497-5500 |
| 英文摘要 | Two natural saponins 1 and 2, isolated from Solanum indicum L., and containing 2,3-branched sugar moieties, have been efficiently synthesized. Partially protected monosaccharide and disaccharide donors were used to facilitate target synthesis. Stereo factors were critical in incorporating 2,3-branched sugars on steroid aglycones. Saponin 1 was synthesized in five steps and 30% overall yield, while saponin 2 was obtained using six straightforward sequential reactions in 31% overall yield. Saponin 2 shows promising cytotoxic activity toward human hepatocellular carcinoma BEL-7402 with an IC50 of <6 mug/mL. |
| 研究领域[WOS] | Chemistry |
| WOS记录号 | WOS:000223008100051 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23446]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gu, GF,Du, YG,Linhardt, RJ. Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors[J]. JOURNAL OF ORGANIC CHEMISTRY,2004,69(16):5497-5500. |
| APA | Gu, GF,Du, YG,&Linhardt, RJ.(2004).Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors.JOURNAL OF ORGANIC CHEMISTRY,69(16),5497-5500. |
| MLA | Gu, GF,et al."Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors".JOURNAL OF ORGANIC CHEMISTRY 69.16(2004):5497-5500. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。