Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin
文献类型：期刊论文
| 作者 | Ding, YS; Yu, H; Mou, SF |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2004 |
| 卷号 | 1039期号:2015-01-02页码:39-43 |
| 关键词 | detection waveforms pulsed amperometric detection neomycin antibiotics aminoglycosides glycosidcs LC |
| 英文摘要 | Determination of neomycin is important for quality control of the pharmaceutical preparation. A quadruple-potential waveform used for pulsed amperometric detection of neomycin was investigated. The waveform cleans the electrode by application of a potential more negative than the potential limit to avoid the formation of gold oxide during applying positive potential to clean gold electrode, thus decreasing the dissolution resulting recession of the gold working electrode within gold oxide formation/reduction cycles in the triple-potential waveform. Waveform parameters were optimized to maximize the signal-to-noise ratio (S/N). The detection limit of neomycin B is lower than 0.01 mug/ml. The linearity of framycetin (plotted as peak area of neomycin B) ranges from 0.05 to 100 mug/ml with correlation coefficient 0.9998. R.S.D. (it = 60) of the peak area of neomycin B is lower than 2%. The quadruple-potential waveform shows low detection limits and long-term reproducibility. (C) 2004 Elsevier B.V. All rights reserved. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23464]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ding, YS,Yu, H,Mou, SF. Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin[J]. JOURNAL OF CHROMATOGRAPHY A,2004,1039(2015-01-02):39-43. |
| APA | Ding, YS,Yu, H,&Mou, SF.(2004).Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin.JOURNAL OF CHROMATOGRAPHY A,1039(2015-01-02),39-43. |
| MLA | Ding, YS,et al."Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin".JOURNAL OF CHROMATOGRAPHY A 1039.2015-01-02(2004):39-43. |
入库方式： OAI收割
来源：生态环境研究中心
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