中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Synthesis and antitumor activities of glucan derivatives

文献类型:期刊论文

作者Du, YG; Gu, GF; Hua, YX; Wei, GH; Ye, XS; Yu, GL
刊名TETRAHEDRON
出版日期2004
卷号60期号:30页码:6345-6351
关键词carbohydrates glycosylations antitumor agents glycodendrimers oligosaccharides
英文摘要A highly efficient and practical method for the preparation of beta-D-Glc-(1-->6)-[beta-D-Glc-(1-->3)]-beta-D-Glc-(1-->6)-beta-D-Glc-(1-->6)-[beta-D-Glc-(1-->3)]-D-Glc-OMe was described. A dendritic nonasaccharide was also synthesized. The antitumor activities of hexasaccharide, the dendrimer, their sulfated derivatives, together with the natural glucan-protein and the corresponding polysaccharide isolated from barmy mycelium of Grifola frondosa, were preliminarily investigated based on Sarcoma-180 studies in mice tests. Our results suggest that the sulfated branching oligosaccharide and natural glycoprotein have better antitumor activities comparing to the parent sugar residue (oligosaccharide or polysaccharide). (C) 2004 Elsevier Ltd. All rights reserved.
研究领域[WOS]Chemistry
WOS记录号WOS:000222712400009
源URL[http://ir.rcees.ac.cn/handle/311016/23485]  
专题生态环境研究中心_环境化学与生态毒理学国家重点实验室
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Du, YG,Gu, GF,Hua, YX,et al. Synthesis and antitumor activities of glucan derivatives[J]. TETRAHEDRON,2004,60(30):6345-6351.
APA Du, YG,Gu, GF,Hua, YX,Wei, GH,Ye, XS,&Yu, GL.(2004).Synthesis and antitumor activities of glucan derivatives.TETRAHEDRON,60(30),6345-6351.
MLA Du, YG,et al."Synthesis and antitumor activities of glucan derivatives".TETRAHEDRON 60.30(2004):6345-6351.

入库方式: OAI收割

来源:生态环境研究中心

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