Synthesis and biological activities of octyl 2,3,4-tri-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-beta-L-fucopyranoside
文献类型：期刊论文
| 作者 | Hua, YX; Gu, GF; Du, YG |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2004 |
| 卷号 | 339期号:4页码:867-872 |
| 关键词 | regioselective silylation fucan sulfated oligosaccharide antitumor activity glycosylation |
| 英文摘要 | An efficient method for the regioselective 3-O-silylation of beta-thiofucopyranoside was disclosed. Based on this discovery, we described a high-yielding strategy for the synthesis of the natural core structure Of L-fucan and its fully sulfated derivative. The bioassay suggested that octyl 2,3,4-tri-O-sulfo-alpha-L-fucopyranosyl-(I --> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(I --> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(l --> 3)-2,4-di-O-sulfo-beta-L-fucopyranoside presented better antitumor activities than that of the free tetramer based on Sarcoma 180 cells and Lewis lung carcinoma model studies. (C) 2004 Elsevier Ltd. All rights reserved. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000220108600015 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23486]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Hua, YX,Gu, GF,Du, YG. Synthesis and biological activities of octyl 2,3,4-tri-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-beta-L-fucopyranoside[J]. CARBOHYDRATE RESEARCH,2004,339(4):867-872. |
| APA | Hua, YX,Gu, GF,&Du, YG.(2004).Synthesis and biological activities of octyl 2,3,4-tri-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-beta-L-fucopyranoside.CARBOHYDRATE RESEARCH,339(4),867-872. |
| MLA | Hua, YX,et al."Synthesis and biological activities of octyl 2,3,4-tri-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2,4-di-O-sulfo-beta-L-fucopyranoside".CARBOHYDRATE RESEARCH 339.4(2004):867-872. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。