Synthesis and biological activities of octyl 2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 -> 4)-2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 -> 4)-2,3-di-O-sulfo-beta-L-fucopyranoside
文献类型：期刊论文
| 作者 | Hua, YX; Du, YG; Yu, GL; Chu, SD |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2004 |
| 卷号 | 339期号:12页码:2083-2090 |
| 关键词 | regioselective silylation fucan sulfated oligosaccharide antitumor activity glycosylation |
| 英文摘要 | Octyl 2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 --> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 --> 4)-2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 --> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 --> 4)-2,3-di-O-sulfo-beta-L-fucopyranoside, a fucosyl pentasaccharide with a regular structure resembling the repeating unit of a natural sulfated fucan, was chemically synthesized using a convergent '2 + 3' strategy. Regioselective 3-O-silylation of beta-thiofucopyranoside and AgOTf-catalyzed glycosylation of the protected glycosyl trichloroacetimidate facilitated a one-pot trisaccharide synthesis. The synthesized target compound showed good antitumor activity in vivo, and promising anticoagulant activity in vitro. (C) 2004 Elsevier Ltd. All rights reserved. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000223352900004 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23487]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Hua, YX,Du, YG,Yu, GL,et al. Synthesis and biological activities of octyl 2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 -> 4)-2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 -> 4)-2,3-di-O-sulfo-beta-L-fucopyranoside[J]. CARBOHYDRATE RESEARCH,2004,339(12):2083-2090. |
| APA | Hua, YX,Du, YG,Yu, GL,&Chu, SD.(2004).Synthesis and biological activities of octyl 2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 -> 4)-2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 -> 4)-2,3-di-O-sulfo-beta-L-fucopyranoside.CARBOHYDRATE RESEARCH,339(12),2083-2090. |
| MLA | Hua, YX,et al."Synthesis and biological activities of octyl 2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 -> 4)-2,3-di-O-sulfo-alpha-L-fucopyranosyl-(1 -> 3)-2-O-sulfo-alpha-L-fucopyranosyl-(1 -> 4)-2,3-di-O-sulfo-beta-L-fucopyranoside".CARBOHYDRATE RESEARCH 339.12(2004):2083-2090. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。