Synthesis of a 6(V)-sulfated mannopentasaccharide analogue related to PI-88
文献类型：期刊论文
| 作者 | Gu, GF; Wei, GH; Du, YG |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2004 |
| 卷号 | 339期号:6页码:1155-1162 |
| 关键词 | sulfated oligosaccharides glycosylation mannose anti-angiogenic |
| 英文摘要 | An efficient and convergent synthesis of a regioselectively 6(v)-sulfated mannopentasaccharide derivative 1c, octyl 6-O-sulfo-alpha -D-mannopyranosyl-(1-->3)-alpha-D-mannopyranosyl-(1-->3)-alpha-D-mannopyranosyl-(1-->3)-alpha-D-mannopyranosyl-(1-->2)-alpha-D-mannopyranoside, was achieved by a '3 + 2' strategy. The target was designed to mimic the promising anticancer agent PI-88 and was obtained from the building blocks, octyl 3,4,6-tri-O-benzoyl-alpha-D-mannopyranoside (3), allyl 2,4,6-tri-O-benzoyl-3-O-(4-methoxybenzyl)-alpha-D-mannopyranoside (6), and 6-O-acetyl-2,3,4-tri-O-benzoyl-alpha-D-mannopyranosyl trichloroacetimidate (11), under TMSOTf-catalyzed glycosylation conditions. Compound le displays a mild anti-angiogenic activity based on a chorio-allantoic membrane (CAM) model study. (C) 2004 Elsevier Ltd. All rights reserved. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000220934200018 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23488]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gu, GF,Wei, GH,Du, YG. Synthesis of a 6(V)-sulfated mannopentasaccharide analogue related to PI-88[J]. CARBOHYDRATE RESEARCH,2004,339(6):1155-1162. |
| APA | Gu, GF,Wei, GH,&Du, YG.(2004).Synthesis of a 6(V)-sulfated mannopentasaccharide analogue related to PI-88.CARBOHYDRATE RESEARCH,339(6),1155-1162. |
| MLA | Gu, GF,et al."Synthesis of a 6(V)-sulfated mannopentasaccharide analogue related to PI-88".CARBOHYDRATE RESEARCH 339.6(2004):1155-1162. |
入库方式： OAI收割
来源：生态环境研究中心
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