Synergic and competitive inhibition effect between two kinds of arylamines in the formation of hemoglobin adduct in vitro
文献类型：期刊论文
| 作者 | Chen, HM; Qin, T; Xu, XB |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
 |
| 出版日期 | 2003 |
| 卷号 | 38期号:2页码:361-370 |
| 关键词 | arylamines hemoglobin adduct model screening synergic effect competitive inhibition effect |
| 英文摘要 | This article presents our work with HPLC-UV to determine hemoglobin adducts produced by adduction reaction among 4-aminobiphenyl (4-ABP) or/and 2-naphthylamine (2-NA) and human hemoglobin in vitro. The results showed that HPLC-UV could efficiently be used to detect aromatic amine-hemoglobin adduct. Two kinds of optimized linear models modified from the traditional dose-response model were screened out. The models implied that synergic effect exists between the two kinds of arylamines adducted with hemoglobin and competitive inhibition effect occurs in the formation of hemoglobin adduct when the two kinds of arylamines are present in the blood synchronously. The results indicate that models for dose-response relationship should take the effects of the other toxicants into consideration in the mixed pollutant system. |
| 研究领域[WOS] | Engineering ; Environmental Sciences & Ecology |
| WOS记录号 | WOS:000181413200004 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23728]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, HM,Qin, T,Xu, XB. Synergic and competitive inhibition effect between two kinds of arylamines in the formation of hemoglobin adduct in vitro[J]. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING,2003,38(2):361-370. |
| APA | Chen, HM,Qin, T,&Xu, XB.(2003).Synergic and competitive inhibition effect between two kinds of arylamines in the formation of hemoglobin adduct in vitro.JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING,38(2),361-370. |
| MLA | Chen, HM,et al."Synergic and competitive inhibition effect between two kinds of arylamines in the formation of hemoglobin adduct in vitro".JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING 38.2(2003):361-370. |
入库方式： OAI收割
来源：生态环境研究中心
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