Effects of lead and selenium on telomere binding protein rap1p, telomerase and telomeric DNA in Saccharomyces cerevisiae
文献类型：期刊论文
| 作者 | Cui, QH; Tang, CC; Huang, YG |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2002 |
| 卷号 | 34期号:2页码:240-244 |
| 关键词 | Saccharomyces cerevisiae Pb and Se telomere length telomerase telomere binding protein Rap1p |
| 英文摘要 | The effects on S. cerevisiae telomere binding protein Rap1p, telomerase and telomeric DNA by the lead (Pb), the selenium (Se) and Pb + Se were tested respectively in this study. Compared with the control S. cerevisiae after 100 generations, the mean telomere length shortened, Rap1p concentration was significantly lower and the secondary structure of Rap1p was disturbed, the telomerase activity was reduced in Pb treated cells. In Se treated cells, telomere length was significantly longer, and telomerase activity expressed higher. The concentration and secondary structure of Raplp were similar to that of the control. Furthermore, the viability of Pb treated cells were significantly reduced while cells undergone other three treatments were similar and normal. These results suggest that Pb could damage Rap1p, reduce telomerase activity, resulting in the telomer length shortening and cell death. On the other hand, Se could protect and repair the damage in Rap1p and telomere caused by Pb to some extent. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| WOS记录号 | WOS:000174549400022 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23878]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Cui, QH,Tang, CC,Huang, YG. Effects of lead and selenium on telomere binding protein rap1p, telomerase and telomeric DNA in Saccharomyces cerevisiae[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2002,34(2):240-244. |
| APA | Cui, QH,Tang, CC,&Huang, YG.(2002).Effects of lead and selenium on telomere binding protein rap1p, telomerase and telomeric DNA in Saccharomyces cerevisiae.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,34(2),240-244. |
| MLA | Cui, QH,et al."Effects of lead and selenium on telomere binding protein rap1p, telomerase and telomeric DNA in Saccharomyces cerevisiae".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 34.2(2002):240-244. |
入库方式： OAI收割
来源：生态环境研究中心
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