The accumulation effect of lead on DNA damage in mice blood cells of three generations and the protection of selenium
文献类型：期刊论文
| 作者 | Yuan, XF; Tang, CC |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
 |
| 出版日期 | 2001 |
| 卷号 | 36期号:4页码:501-508 |
| 关键词 | accumulation effects lead DNA damage mice blood cells protection selenium |
| 英文摘要 | The accumulation effect of lead on DNA damage and the protection of selenium against lead were studied in mice blood cells of three generations. The test animals were divided into four groups: controls, Ph group, Se group, Pb + Se group. Lead and Selenium were administered to mice in the drinking water. The concentrations of lead tin form of lead acetate) and selenium tin form of Kappa-selenocarrageenan) used in this paper were 1 mug/ml and 0.25 mug/ml respectively. The percentage of damaged cells (DNA comets) was examined and detected conveniently by the single-cell gel electrophoresis (comet) assay. Results showed that 1 mug/ml lead did not damage the female mice blood cells of the first generation seriously. However, there was a significant damage effect in both sexes of the second and third generations, suggesting the accumulation effect of lead was very significant starting from the second generation. Tn addition, under normal physiological conditions, Kappa-Se did not appear to enhance the protective ability on DNA damage significantly, whereas under lead exposure conditions, administration of Kappa-Se displayed the occurrence of a good protection against lead intoxication which was started from the female mice of the second generation. |
| WOS记录号 | WOS:000170042900009 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/24039]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yuan, XF,Tang, CC. The accumulation effect of lead on DNA damage in mice blood cells of three generations and the protection of selenium[J]. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING,2001,36(4):501-508. |
| APA | Yuan, XF,&Tang, CC.(2001).The accumulation effect of lead on DNA damage in mice blood cells of three generations and the protection of selenium.JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING,36(4),501-508. |
| MLA | Yuan, XF,et al."The accumulation effect of lead on DNA damage in mice blood cells of three generations and the protection of selenium".JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING 36.4(2001):501-508. |
入库方式： OAI收割
来源：生态环境研究中心
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