Reductive metabolism of 4-nitrobiphenyl by rat liver fraction
文献类型：期刊论文
| 作者 | Ning, S; Xu, XB |
| 刊名 | CARCINOGENESIS
 |
| 出版日期 | 1997 |
| 卷号 | 18期号:6页码:1233-1240 |
| 英文摘要 | The metabolites of 4-nitrobiphenyl (4-NBP) mere studied using S-9 under anaerobic conditions. Ten metabolites mere isolated and tentatively identified by high-performance liquid chromatography/atmospheric pressure chemical ionization/mass spectrometry (HPLC/APCI/MS), which is a novel efficient technqiue for analyses of metabolites, HPLC retention times and UV spectra have been also used for the confirmation, Among them, 4-aminobiphenyl (4-ABP, 79% of total metabolites) and hydroxylaminobiphenyls were found to be the major metabolites, and 4-acetylaminobiphenyl (4-AABP), N-hydroxy-4-acetylaminobiphenyl (4-AABP-N-OH), x-OH-4-nitrobiphenyl biphenylene and N-formyl-4-aminobiphenyl (N-formyl-4-ABP) were the minor metabolites, Based on the metabolities identified, different metabolic pathways of 4-NBP in rat liver, including N-hydroxylation, N-acetylation, N-formylation, de-nitro-group biotransformation and ring hydroxylation mere proposed to elucidate the mechanisms of toxification and detoxification, In addition, experimental conditions such as incubation time and S-9 amounts were optimized. |
| WOS记录号 | WOS:A1997XF49500015 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/24346]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ning, S,Xu, XB. Reductive metabolism of 4-nitrobiphenyl by rat liver fraction[J]. CARCINOGENESIS,1997,18(6):1233-1240. |
| APA | Ning, S,&Xu, XB.(1997).Reductive metabolism of 4-nitrobiphenyl by rat liver fraction.CARCINOGENESIS,18(6),1233-1240. |
| MLA | Ning, S,et al."Reductive metabolism of 4-nitrobiphenyl by rat liver fraction".CARCINOGENESIS 18.6(1997):1233-1240. |
入库方式： OAI收割
来源：生态环境研究中心
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