Effects of pentachlorophenol on the reproduction of Japanese medaka (Oryzias latipes)
文献类型：期刊论文
| 作者 | Zha, JM; Wang, ZJ; Schlenk, D |
| 刊名 | CHEMICO-BIOLOGICAL INTERACTIONS
 |
| 出版日期 | 2006 |
| 卷号 | 161期号:1页码:26-36 |
| 关键词 | pentachlorophenol Japanese medaka (Oryzias latipes) EROD vitellogenin reproduction impairment |
| 英文摘要 | Pentachlorophenol (PCP) is widely used to control termites and protect wood from fungal-rot and wood-boring insects, and is often detected in the aquatic environment. Few studies have evaluated PCP as an environmental endocrine disruptor. In the present work, Japanese medaka (Oryzias latipes) was exposed to PCP for 28 days (FO generation) with subsequent measurements of vitellogenin (VTG), hepatic 7-ethoxyresorufin-O-deethylase (EROD), and reproductive endpoints. Plasma VTG significantly increased in male fish treated with PCP concentrations lower than 200 mu g/l and decreased in male and female animals exposed to 200 mu g/l. Hepatic EROD from female fish increased when PCP exposure concentrations exceeded 20 mu g/l, but decreased in the 200 mu g/l PCP treatment group. Fecundity and mean fertility of female medaka decreased significantly in the second and third week following exposure concentrations greater than 100 mu g/l, and testis-ova of male medaka was observed at PCP concentrations greater than 50 mu g/l. Histological lesions of liver and kidney occurred when exposure concentrations exceeded 50 mu g/l. In F1 generations, the hatching rates and time to hatch of offspring were significantly affected in fish exposed to 200 mu g/l. These results indicated that PCP exposure caused responses consistent with estrogen and aryl hydrocarbon receptor activation as well as reproductive impairment at environmentally relevant concentrations. (c) 2006 Published by Elsevier Ireland Ltd. |
| WOS记录号 | WOS:000237882200003 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22986]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zha, JM,Wang, ZJ,Schlenk, D. Effects of pentachlorophenol on the reproduction of Japanese medaka (Oryzias latipes)[J]. CHEMICO-BIOLOGICAL INTERACTIONS,2006,161(1):26-36. |
| APA | Zha, JM,Wang, ZJ,&Schlenk, D.(2006).Effects of pentachlorophenol on the reproduction of Japanese medaka (Oryzias latipes).CHEMICO-BIOLOGICAL INTERACTIONS,161(1),26-36. |
| MLA | Zha, JM,et al."Effects of pentachlorophenol on the reproduction of Japanese medaka (Oryzias latipes)".CHEMICO-BIOLOGICAL INTERACTIONS 161.1(2006):26-36. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。