Three-Component Reactions of Aromatic Aldehydes and Two Different Nucleophiles and their Leaving Ability-Determined Downstream Conversions of the Products
文献类型：期刊论文
| 作者 | Li, Minghao1; Taheri, Amir1; Liu, Meng1; Sun, Shaohuan1; Gu YL(顾彦龙)1,2 |
| 刊名 | Advanced Synthesis & Catalysis
 |
| 出版日期 | 2014 |
| 卷号 | 356期号:2-3页码:537-556 |
| 关键词 | carbon-carbon bond formation leaving groups L-proline S(N)1 reactions three-component reactions |
| ISSN号 | 1615-4150 |
| 通讯作者 | 顾彦龙 |
| 英文摘要 | Many three-component reactions of aromatic aldehydes with activated methylene derivatives and an associated nucleophile have been developed by using L-proline as the catalyst. Nucleophiles, such as indoles, thiophenols, mercaptans, 2-methylfuran and benzenesulfinic acid, could be successfully used in the reactions while the activated methylene derivatives can be 1,3-cyclohexanedione, dimedone, 1,3-cyclopentanedione, 1-phenyl-3-methyl-5-pyrazolone, 4-hydroxycoumarin, 4,6-dihydroxy-2-mercaptopyrimidine, 4-hydroxy-1-methyl-2quinolone, 4-hydroxy-6-methyl-2-pyrone and 2-hydroxy-1,4-naphthoquinone. Investigation of the downstream utilization of the products from the above multicomponent reactions (MCRs) revealed that selective cleavages of carbon-carbon and carbon-heteroatom bonds in these molecules are indeed possible, which opens an avenue to access some new S(N)1-type reactions. Particularly, when the MCR product of an aromatic aldehyde, dimedone and thiophenol was treated with an acid catalyst in the presence of an appropriate nucleophile, cleavage of the carbon-sulfur bond occurred preferentially, thus providing many complex molecules that cannot be attained by other known methods. |
| 学科主题 | 物理化学与绿色催化 |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China (21173089;21373093);the Program for New Century Excellent Talents in the University of China (NCET-10-0383);Chutian Scholar Program of the Hubei provincial goverment and Cooperative Innovation Center of Catalysts Materials of Hubei Province |
| 语种 | 英语 |
| WOS记录号 | WOS:000332000200036 |
| 源URL | [http://210.77.64.217/handle/362003/18310]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Key Lab Large Format Battery Mat & Syst, Minist Educ, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Minghao,Taheri, Amir,Liu, Meng,et al. Three-Component Reactions of Aromatic Aldehydes and Two Different Nucleophiles and their Leaving Ability-Determined Downstream Conversions of the Products[J]. Advanced Synthesis & Catalysis,2014,356(2-3):537-556. |
| APA | Li, Minghao,Taheri, Amir,Liu, Meng,Sun, Shaohuan,&Gu YL.(2014).Three-Component Reactions of Aromatic Aldehydes and Two Different Nucleophiles and their Leaving Ability-Determined Downstream Conversions of the Products.Advanced Synthesis & Catalysis,356(2-3),537-556. |
| MLA | Li, Minghao,et al."Three-Component Reactions of Aromatic Aldehydes and Two Different Nucleophiles and their Leaving Ability-Determined Downstream Conversions of the Products".Advanced Synthesis & Catalysis 356.2-3(2014):537-556. |
入库方式： OAI收割
来源：兰州化学物理研究所
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