Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases
文献类型：期刊论文
| 作者 | Jia L(贾磊)1,2; Cai, Hong-xin1; Xu, Jun1; Zhou, Heng3; Wu, Wei-na1; Li, Fei-fei1; Wang, Yuan1; Pei XW(裴小维)2 ; Wang, Qin3
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| 刊名 | Inorganic Chemistry Communications
 |
| 出版日期 | 2013 |
| 卷号 | 35页码:16-18 |
| 关键词 | Cell apoptosis Cytotoxicity DNA binding properties Reduce Schiff base Hoechst 33258 Ternary Cu(II) complexes |
| ISSN号 | 1387-7003 |
| 通讯作者 | 贾磊 ; Wang, Qin |
| 英文摘要 | Three mononuclear mixed ligand Cu(II) complexes of the type [Cu(L)(DTHA)]H2O center dot CH3OH, where H2DTHA is 2-(3,5-di-tert-butyl-2-hydroxybenzylamino) acetic acid and the co-ligand L is 1,10-phenanthroline (phen, 1), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 2) dipyrido [3,2-a:2',3'-c]phenazine (dppz, 3) have been isolated and characterized. Absorption and emission spectral studies and viscosity measurements indicated that 3 interacts with DNA more strongly than all of the other complexes through intercalation mode. Furthermore, cytotoxicity studies on the tested four cell line indicated that they can efficiently inhibit the cell proliferation in a time-dependent manner, and the Hoechst 33258 staining assays have also been employed in finding the extent of DNA damage. |
| 学科主题 | 材料科学与物理化学 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327361400005 |
| 源URL | [http://210.77.64.217/handle/362003/18098]  |
| 专题 | 兰州化学物理研究所_固体润滑国家重点实验室 |
| 作者单位 | 1.Henan Polytech Univ, Dept Chem & Phys, Jiaozuo 454000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Sch Life Sci, Inst Canc Biol & Drug Screening, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia L,Cai, Hong-xin,Xu, Jun,et al. Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases[J]. Inorganic Chemistry Communications,2013,35:16-18. |
| APA | Jia L.,Cai, Hong-xin.,Xu, Jun.,Zhou, Heng.,Wu, Wei-na.,...&Wang, Qin.(2013).Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases.Inorganic Chemistry Communications,35,16-18. |
| MLA | Jia L,et al."Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases".Inorganic Chemistry Communications 35(2013):16-18. |
入库方式： OAI收割
来源：兰州化学物理研究所
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