Low-Temperature Hydrothermal Synthesis of Hierarchical Porous Hydroxyapatite Microsphere with Co-substituted Essential Trace Elements for pH-responsive Drug Delivery
文献类型：期刊论文
| 作者 | Wang S(王莎)1,2; Guo ZG(郭志光)1,2
|
| 刊名 | Nano Life
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:1页码:154001(1-12) |
| 关键词 | Porous hydroxyapatite microsphere drug delivery hydrothermal method degradation |
| ISSN号 | 1793-9844 |
| 通讯作者 | 郭志光 |
| 英文摘要 | Hierarchical hydroxyapatite microspheres composed of two porous hemispherulites have been synthesized hydrothermally at 80_C. A possible formation mechanism was proposed. The drug loading and release properties were further investigated. 3D hierarchical microspheric hydroxyapatite (HAp) composed of two porous hemispherulites was hydrothermally fabricated at low temperature with the aid of urea and NaNO3, Mg(NO3)2, KNO3, NH4Cl and NH4F as the homogeneous precipitation reagent and substituted ion sources. In this novel strategy, the element-substitutions serve as regulating agents for the self-assembly of porous HAp microspheres from the dumbbell-like particles to two hemispheres with radius of about 10 μm. Furthermore, the as-prepared hierarchical HAp microspheres exhibit high drug-loading capability and superior sustained release properties, which make it a promising carrier for pH responsive drug delivery system. |
| 学科主题 | 材料科学与物理化学 |
| 资助信息 | the National Nature Science Foundation of China (No. 31070155;11172301;21203217);the “Funds for Distinguished Young Scientists” of Hubei Province (2012FFA002);the “Western Light Talent Culture" Project;the Co-joint Project of Chinese Academy of Sciences;the “Top Hundred Talents" Program of Chinese Academy of Sciences;the National 973 Project (2013CB632300) |
| 语种 | 英语 |
| 源URL | [http://210.77.64.217/handle/362003/18824]  |
| 专题 | 兰州化学物理研究所_固体润滑国家重点实验室 |
| 作者单位 | 1.Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University Wuhan 430062, P. R. China 2.State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences Lanzhou 730000, P. R. China |
| 推荐引用方式 GB/T 7714 | Wang S,Guo ZG. Low-Temperature Hydrothermal Synthesis of Hierarchical Porous Hydroxyapatite Microsphere with Co-substituted Essential Trace Elements for pH-responsive Drug Delivery[J]. Nano Life,2015,5(1):154001(1-12). |
| APA | Wang S,&Guo ZG.(2015).Low-Temperature Hydrothermal Synthesis of Hierarchical Porous Hydroxyapatite Microsphere with Co-substituted Essential Trace Elements for pH-responsive Drug Delivery.Nano Life,5(1),154001(1-12). |
| MLA | Wang S,et al."Low-Temperature Hydrothermal Synthesis of Hierarchical Porous Hydroxyapatite Microsphere with Co-substituted Essential Trace Elements for pH-responsive Drug Delivery".Nano Life 5.1(2015):154001(1-12). |
入库方式： OAI收割
来源：兰州化学物理研究所
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