Biocompatible Magnetic and Molecular Dual-Targeting Polyelectrolyte Hybrid Hollow Microspheres for Controlled Drug Release
文献类型：期刊论文
| 作者 | Du, Pengcheng1,2; Zeng, Jin1,2; Mu B(牟斌)3 ; Liu P(刘鹏)1,2
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| 刊名 | Molecular Pharmaceutics
 |
| 出版日期 | 2013 |
| 卷号 | 10期号:5页码:1705-1715 |
| 关键词 | biocompatible polyelectrolyte hybrid hollow microspheres magnetic and molecular dual-targeting pH and ionic strength dual-responsive layer-by-layer assembly aggregation-resistant |
| ISSN号 | 1543-8384 |
| 通讯作者 | 刘鹏 |
| 英文摘要 | Well-defined biocompatible magnetic and molecular dual-targeting polyelectrolyte hybrid hollow microspheres have been accomplished via the layer-by-layer (LbL) self-assembly technique. The hybrid shell was fabricated by the electrostatic interaction between the polyelectrolyte cation, chitosan (CS), and the hybrid anion, citrate modified ferroferric oxide nanoparticles (Fe3O4-CA), onto the uniform polystyrene sulfonate microsphere templates. Then the magnetic hybrid core/shell composite particles were modified with a linear, functional poly(ethylene glycol) (PEG) monoterminated with a biotargeting molecule (folic acid (FA)). Afterward the dual targeting hybrid hollow microspheres were obtained after etching the templates by dialysis. The dual targeting hybrid hollow microspheres exhibit exciting pH response and stability in high salt-concentration media. Their pH-dependent controlled release of the drug molecule (anticancer drug, doxorubicin (DOX)) was also investigated in different human body fluids. As expected, the cell viability of the HepG2 cells which decreased more rapidly was treated by the FA modified hybrid hollow microspheres rather than the unmodified one in the in vitro study. The dual-targeting hybrid hollow microspheres demonstrate selective killing of the tumor cells. The precise magnetic and molecular targeting properties and pH-dependent controlled release offers promise for cancer treatment. |
| 学科主题 | 环境材料与生态化学 |
| 收录类别 | SCI |
| 资助信息 | the National Nature Science Foundation of China (Grant No. 20904017);the Program for New Century Excellent Talents in University (Grant No. NCET-09-0441);the Fundamental Research Funds for the Central Universities (Grant No. lzujbky-2012-k12) |
| 语种 | 英语 |
| WOS记录号 | WOS:000318669600020 |
| 源URL | [http://210.77.64.217/handle/362003/18249]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 作者单位 | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Inst Polymer Sci & Engn, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Pengcheng,Zeng, Jin,Mu B,et al. Biocompatible Magnetic and Molecular Dual-Targeting Polyelectrolyte Hybrid Hollow Microspheres for Controlled Drug Release[J]. Molecular Pharmaceutics,2013,10(5):1705-1715. |
| APA | Du, Pengcheng,Zeng, Jin,Mu B,&Liu P.(2013).Biocompatible Magnetic and Molecular Dual-Targeting Polyelectrolyte Hybrid Hollow Microspheres for Controlled Drug Release.Molecular Pharmaceutics,10(5),1705-1715. |
| MLA | Du, Pengcheng,et al."Biocompatible Magnetic and Molecular Dual-Targeting Polyelectrolyte Hybrid Hollow Microspheres for Controlled Drug Release".Molecular Pharmaceutics 10.5(2013):1705-1715. |
入库方式： OAI收割
来源：兰州化学物理研究所
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