A Comparative Study on the Self-Assembly of an Amyloid-Like Peptide at Water-Solid Interfaces and in Bulk Solutions
文献类型：期刊论文
| 作者 | Du, QQG; Dai, B; Hou, JH; Hu, J; Zhang, F; Zhang, Y |
| 刊名 | MICROSCOPY RESEARCH AND TECHNIQUE
 |
| 出版日期 | 2015 |
| 卷号 | 78期号:5页码:375—381 |
| 关键词 | ATOMIC-FORCE MICROSCOPY BETA-SHEET TAPES NANOFIBER SCAFFOLD FIBRIL FORMATION ALPHA-SYNUCLEIN NANOTUBES PROTEIN NANOFILAMENTS MECHANISM SURFACES |
| 英文摘要 | In the past years the self-assembly of amyloid-like peptides has attracted increasing attentions, because it is highly related to neurodegenerative diseases and has a potential for serving as nanomaterial to fabricate novel and useful nanostructures. In this paper, we focused on the role of interfacial conditions in the self-assembly of an amyloid-like peptide, termed Pep11. It was found that, when dissolved in bulk solutions, Pep11 formed into -sheet structures and assembled into long filaments in several hours, as revealed by Thioflavin T fluorescence and transmission electron microscopy (TEM) morphology characterization, respectively. When the peptide solution was added onto a mica/HOPG substrate, peptide filaments with three preferred orientations with an angle of 60 degrees to each other were formed immediately, as imaged in situ by atomic force microscopy (AFM). However, the kinetics in filament formation and the morphologies of the formed beta sheet either on HOPG and mica or in bulk solutions were quite different. These results indicate that the interfacial properties dramatically affect the peptide self-assembly process. Microsc. Res. Tech. 78:375-381, 2015. (c) 2015 Wiley Periodicals, Inc. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24369]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Du, QQG,Dai, B,Hou, JH,et al. A Comparative Study on the Self-Assembly of an Amyloid-Like Peptide at Water-Solid Interfaces and in Bulk Solutions[J]. MICROSCOPY RESEARCH AND TECHNIQUE,2015,78(5):375—381. |
| APA | Du, QQG,Dai, B,Hou, JH,Hu, J,Zhang, F,&Zhang, Y.(2015).A Comparative Study on the Self-Assembly of an Amyloid-Like Peptide at Water-Solid Interfaces and in Bulk Solutions.MICROSCOPY RESEARCH AND TECHNIQUE,78(5),375—381. |
| MLA | Du, QQG,et al."A Comparative Study on the Self-Assembly of an Amyloid-Like Peptide at Water-Solid Interfaces and in Bulk Solutions".MICROSCOPY RESEARCH AND TECHNIQUE 78.5(2015):375—381. |
入库方式： OAI收割
来源：上海应用物理研究所
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