Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography
文献类型：期刊论文
| 作者 | Lin, XJ; Miao, P; Mu, ZH; Jiang, Z; Lu, YF; Guan, YJ; Chen, XY; Xiao, TQ; Wang, YT; Yang, GY |
| 刊名 | PHYSICS IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 60期号:4页码:1655—1665 |
| 关键词 | BLOOD-FLOW VASCULAR FUNCTION BRAIN ISCHEMIA ANGIOGENESIS VOLUME RATS |
| 英文摘要 | The lenticulostriate artery plays a vital role in the onset and development of cerebral ischemia. However, current imaging techniques cannot assess the in vivo functioning of small arteries such as the lenticulostriate artery in the brain of rats. Here, we report a novel method to achieve a high resolution multi-functional imaging of the cerebrovascular system using synchrotron radiation angiography, which is based on spatio-temporal analysis of contrast density in the arterial cross section. This method provides a unique tool for studying the sub-cortical vascular elasticity after cerebral ischemia in rats. Using this technique, we demonstrated that the vascular elasticity of the lenticulostriate artery decreased from day 1 to day 7 after transient middle cerebral artery occlusion in rats and recovered from day 7 to day 28 compared to the controls (p < 0.001), which paralleled with brain edema formation and inversely correlated with blood flow velocity (p < 0.05). Our results demonstrated that the change of vascular elasticity was related to the levels of brain edema and the velocity of focal blood flow, suggesting that reducing brain edema is important for the improvement of the function of the lenticulostriate artery in the ischemic brain. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24427]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Lin, XJ,Miao, P,Mu, ZH,et al. Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography[J]. PHYSICS IN MEDICINE AND BIOLOGY,2015,60(4):1655—1665. |
| APA | Lin, XJ.,Miao, P.,Mu, ZH.,Jiang, Z.,Lu, YF.,...&Yang, GY.(2015).Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography.PHYSICS IN MEDICINE AND BIOLOGY,60(4),1655—1665. |
| MLA | Lin, XJ,et al."Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography".PHYSICS IN MEDICINE AND BIOLOGY 60.4(2015):1655—1665. |
入库方式： OAI收割
来源：上海应用物理研究所
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