Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery
文献类型：期刊论文
| 作者 | Yan, J; Hu, CY; Wang, P; Zhao, B; Ouyang, XY; Zhou, J; Liu, R; He, DN; Fan, CH; Song, SP |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2015 |
| 卷号 | 54期号:8页码:2431—2435 |
| 关键词 | ROLLING CIRCLE AMPLIFICATION QUANTUM DOTS GOLD NANOPARTICLES BIOMEDICAL APPLICATIONS INTRACELLULAR DELIVERY LIVING CELLS PEPTIDES CARRIER NANOSTRUCTURES DIAGNOSTICS |
| 英文摘要 | A novel three-dimensional (3D) superstructure based on the growth and origami folding of DNA on gold nanoparticles (AuNPs) was developed. The 3D superstructure contains a nanoparticle core and dozens of two-dimensional DNA belts folded from long single-stranded DNAs grown insitu on the nanoparticle by rolling circle amplification (RCA). We designed two mechanisms to achieve the loading of molecules onto the 3D superstructures. In one mechanism, ligands bound to target molecules are merged into the growing DNA during the RCA process (merging mechanism). In the other mechanism, target molecules are intercalated into the double-stranded DNAs produced by origami folding (intercalating mechanism). We demonstrated that the as-fabricated 3D superstructures have a high molecule-loading capacity and that they enable the high-efficiency transport of signal reporters and drugs for cellular imaging and drug delivery, respectively. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24467]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Yan, J,Hu, CY,Wang, P,et al. Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(8):2431—2435. |
| APA | Yan, J.,Hu, CY.,Wang, P.,Zhao, B.,Ouyang, XY.,...&Song, SP.(2015).Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(8),2431—2435. |
| MLA | Yan, J,et al."Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.8(2015):2431—2435. |
入库方式： OAI收割
来源：上海应用物理研究所
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