Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity
文献类型：期刊论文
| 作者 | Ren, J; Yang, M; Liu, HC; Cao, DY; Chen, DQ; Li, J; Tang, L; He, JH; Chen, YL; Geng, MY |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:5页码:1531—1535 |
| 关键词 | HEAT-SHOCK PROTEINS 3-COMPONENT CONDENSATION DISCOVERY HEAT-SHOCK-PROTEIN-90 IDENTIFICATION PYRAZINES POTENT CHAPERONE |
| 英文摘要 | Using a 2,3-diamino pyrazine substrate and yttrium triflate catalyst, various 2-alkyl and aryl substituted 3,8-diaminoimidazo[1,2-a]pyrazines were efficiently prepared through Groebke-Blackburn-Bienayme MCR. In particular, a novel 2-piperonyl 3,8-diaminoimidazo[1,2-a]pyrazine structure was prepared exclusively with this new method and was found to have moderate Hsp90 inhibitory activity. A crystalline complex with N-terminus ATP domain of Hsp90 and one of the new Hsp90 inhibitors was also obtained to elucidate the origin of activity of 2-piperonyl 3,8-diaminoimidazo[1,2-a]pyrazines. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24505]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Ren, J,Yang, M,Liu, HC,et al. Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(5):1531—1535. |
| APA | Ren, J.,Yang, M.,Liu, HC.,Cao, DY.,Chen, DQ.,...&Shen, JK.(2015).Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity.ORGANIC & BIOMOLECULAR CHEMISTRY,13(5),1531—1535. |
| MLA | Ren, J,et al."Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity".ORGANIC & BIOMOLECULAR CHEMISTRY 13.5(2015):1531—1535. |
入库方式： OAI收割
来源：上海应用物理研究所
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