Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid
文献类型：期刊论文
| 作者 | Xu, YL; Liu, YC; Li, HX; Zhang, P; Zhao, JF; Wang, WF |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 58期号:3页码:508—513 |
| 关键词 | PULSE-RADIOLYSIS AQUEOUS-SOLUTION IN-VITRO DNA-DAMAGE CIPROFLOXACIN FLUOROQUINOLONES PHOTOTOXICITY QUINOLONES OXIDATION VIVO |
| 英文摘要 | Laser flash photolysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) experiments were carried out to study the photosensitive damage induced by pazufloxacin (PAX) and the protection of lysozyme (Lyso) by ferulic acid (FCA), an active antioxidant. Transient absorption spectra revealed electron transfer from Lyso and FCA to (3)PAX*, with respective bimolecular reaction rate constants of 6.3x10(7) and 1.4x10(10) dm(3)/(mol s). A pulse radiolysis study was also performed to investigate the formation of Lyso radical cations. Results showed that FCA effectively inhibits the cross-linking of protein induced by fluoroquinolones. Finally, a mechanism of the protective effect of FCA on Lyso was proposed. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24533]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Xu, YL,Liu, YC,Li, HX,et al. Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid[J]. SCIENCE CHINA-CHEMISTRY,2015,58(3):508—513. |
| APA | Xu, YL,Liu, YC,Li, HX,Zhang, P,Zhao, JF,&Wang, WF.(2015).Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid.SCIENCE CHINA-CHEMISTRY,58(3),508—513. |
| MLA | Xu, YL,et al."Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid".SCIENCE CHINA-CHEMISTRY 58.3(2015):508—513. |
入库方式： OAI收割
来源：上海应用物理研究所
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