Rational Designed Bipolar, Conjugated Polymer-DNA Composite Beacon for the Sensitive Detection of Proteins and Ions
文献类型：期刊论文
| 作者 | Jia, YM; Zuo, XL; Lou, XD; Miao, M; Cheng, Y; Min, XH; Li, XC; Xia, F |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 87期号:7页码:3890—3894 |
| 关键词 | ENHANCED RAMAN-SCATTERING HUMAN TELOMERASE ACTIVITY MOLECULAR BEACONS ELECTROCHEMICAL BIOSENSOR ULTRASENSITIVE DETECTION CARBON NANOTUBES IN-VITRO APTAMER CELLS HYBRIDIZATION |
| 英文摘要 | Nature owns remarkable capabilities in sensing target molecules, while the artificial biosensor lags far behind nature. Inspired by nature, we devise a new sensing platform that can specifically bind the molecules and synchronously initiate a specific signal response. We rationally designed a type of bipolar probe that is comprised of a hydrophilic DNA part and a hydrophobic conjugated polymer (CP) unit. In aqueous solution, they can form micelles with a hydrophobic CP core and a hydrophilic DNA shell. The aggregation-caused quenching suppresses the fluorescence of CP. Adding telomerase, the hydropathical profile of the bipolar probes is drastically regulated that results in the collapse of micelles and liberates fluorescence simultaneously. The probe has been used in both mimic systems and real urine samples (38 samples). We achieve sensitive and specific detection of telomerase and obtain clearly classification for normal people and cancer patients. It can also be used in a signal off sensor that is used to detect mercury ions. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24551]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Jia, YM,Zuo, XL,Lou, XD,et al. Rational Designed Bipolar, Conjugated Polymer-DNA Composite Beacon for the Sensitive Detection of Proteins and Ions[J]. ANALYTICAL CHEMISTRY,2015,87(7):3890—3894. |
| APA | Jia, YM.,Zuo, XL.,Lou, XD.,Miao, M.,Cheng, Y.,...&Xia, F.(2015).Rational Designed Bipolar, Conjugated Polymer-DNA Composite Beacon for the Sensitive Detection of Proteins and Ions.ANALYTICAL CHEMISTRY,87(7),3890—3894. |
| MLA | Jia, YM,et al."Rational Designed Bipolar, Conjugated Polymer-DNA Composite Beacon for the Sensitive Detection of Proteins and Ions".ANALYTICAL CHEMISTRY 87.7(2015):3890—3894. |
入库方式： OAI收割
来源：上海应用物理研究所
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