Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier
文献类型：期刊论文
| 作者 | Dai, B; Li, D; Xi, W; Luo, F; Zhang, X; Zou, M; Cao, M; Hu, J; Wang, WY; Wei, GH |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2015 |
| 卷号 | 112期号:10页码:2996—3001 |
| 关键词 | BUILDING-BLOCKS FIBRILS PROTEINS NANOTUBES DISEASE NANOMATERIALS DESIGN |
| 英文摘要 | Using and engineering amyloid as nanomaterials are blossoming trends in bionanotechnology. Here, we show our discovery of an amyloid structure, termed "amyloid-like nanosheet," formed by a key amyloid-forming segment of Alzheimer's A beta. Combining multiple biophysical and computational approaches, we proposed a structural model for the nanosheet that is formed by stacking the amyloid fibril spines perpendicular to the fibril axis. We further used the nanosheet for laboratorial retroviral transduction enhancement and directly visualized the presence of virus on the nanosheet surface by electron microscopy. Furthermore, based on our structural model, we designed nanosheet-forming peptides with different functionalities, elucidating the potential of rational design for amyloid-based materials with novel architecture and function. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24613]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Dai, B,Li, D,Xi, W,et al. Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015,112(10):2996—3001. |
| APA | Dai, B.,Li, D.,Xi, W.,Luo, F.,Zhang, X.,...&Liu, C.(2015).Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,112(10),2996—3001. |
| MLA | Dai, B,et al."Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112.10(2015):2996—3001. |
入库方式： OAI收割
来源：上海应用物理研究所
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