Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder
文献类型：期刊论文
| 作者 | Zhu, CZ; Zang, YF; Liang, M ; Tian, LX; He, Y; Li, XB; Sui, MQ; Wang, YF; Jiang, TZ; Duncan, JS
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| 刊名 | MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2
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| 出版日期 | 2005 |
| 卷号 | 3750页码:468-475 |
| 英文摘要 | In this work, a discriminative model of attention deficit hyperactivity disorder (ADHD) is presented on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model consists of two parts, a classifier and an intuitive representation of discriminative pattern of brain function between patients and normal controls. Regional homogeneity (ReHo), a measure of brain function at resting-state, is used here as a feature of classification. Fisher discriminative analysis (FDA) is performed on the features of training samples and a linear classifier is generated. Our initial experimental results show a successful classification rate of 85%, using leave-one-out cross validation. The classifier is also compared with linear support vector machine (SVM) and Batch Perceptron. Our classifier outperforms the alternatives significantly. Fisher brain, the optimal projective-direction vector in FDA, is used to represent the discriminative pattern. Some abnormal brain regions identified by Fisher brain, like prefrontal cortex and anterior cingulate cortex, are well consistent with that reported in neuroimaging studies on ADHD. Moreover, some less reported but highly discriminative regions are also identified. We conclude that the discriminative model has potential ability to improve current diagnosis and treatment evaluation of ADHD. |
| WOS标题词 | Science & Technology ; Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Computer Science, Information Systems ; Computer Science, Theory & Methods ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Computer Science ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | DEFICIT HYPERACTIVITY DISORDER ; ALZHEIMERS-DISEASE ; MAGNETIC-RESONANCE ; CLASSIFICATION ; CONNECTIVITY ; MRI ; FLUCTUATIONS ; CEREBELLUM ; IMAGES ; CORTEX |
| 收录类别 | ISTP ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000233356900058 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9069]  |
| 专题 | 自动化研究所_09年以前成果 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100864, Peoples R China 2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, CZ,Zang, YF,Liang, M,et al. Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder[J]. MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2,2005,3750:468-475. |
| APA | Zhu, CZ.,Zang, YF.,Liang, M.,Tian, LX.,He, Y.,...&Gerig, G.(2005).Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder.MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2,3750,468-475. |
| MLA | Zhu, CZ,et al."Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder".MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2 3750(2005):468-475. |
入库方式： OAI收割
来源：自动化研究所
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