Exploring candidate genes for human brain diseases from a brain-specific gene network
文献类型：期刊论文
| 作者 | Liu, Bing ; Jiang, Tianzi; Ma, Songde; Zhao, Huizhi; Li, Jun; Jiang, Xingpeng; Zhang, Jing
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| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006-11-03 |
| 卷号 | 349期号:4页码:1308-1314 |
| 关键词 | Bayesian statistical model brain-specific gene network subnetwork candidate genes |
| 英文摘要 | It is believed that large numbers of genes are involved in common human brain diseases. Here, we propose a novel computational strategy for simultaneously identifying multiple candidate genes for genetic human brain diseases from a brain-specific gene network-level perspective. By integrating diverse genomic and proteomic datasets based on Bayesian statistical model, we built a large-scale human brain-specific gene network. Based on this network and minor prior knowledge of a specific brain disease, we can effectively identify multiple candidate genes for this disease. When four known Alzheimer's disease genes were used as the prior knowledge, among the top 46 high-scoring genes that we have found, 37 were previously reported to be associated with Alzheimer's disease. And the higher score a gene has, the more likely this gene is a disease-related one. The results suggest that the proposed method is effective, convenient, and applicable in the future genetic studies. (c) 2006 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | PROTEIN-PROTEIN INTERACTIONS ; ALZHEIMERS-DISEASE ; ASSOCIATION ; INTERACTOME ; MAP |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000241064800019 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9242]  |
| 专题 | 自动化研究所_09年以前成果 |
| 作者单位 | Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Bing,Jiang, Tianzi,Ma, Songde,et al. Exploring candidate genes for human brain diseases from a brain-specific gene network[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,349(4):1308-1314. |
| APA | Liu, Bing.,Jiang, Tianzi.,Ma, Songde.,Zhao, Huizhi.,Li, Jun.,...&Zhang, Jing.(2006).Exploring candidate genes for human brain diseases from a brain-specific gene network.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,349(4),1308-1314. |
| MLA | Liu, Bing,et al."Exploring candidate genes for human brain diseases from a brain-specific gene network".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 349.4(2006):1308-1314. |
入库方式： OAI收割
来源：自动化研究所
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