Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation
文献类型：期刊论文
| 作者 | Lv, Yujie; Tian, Jie ; Cong, Wenxiang; Wang, Ge; Yang, Wei; Qin, Chenghu; Xu, Min
|
| 刊名 | PHYSICS IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2007-08-07 |
| 卷号 | 52期号:15页码:4497-4512 |
| 关键词 | bioluminescence |
| 通讯作者 | Tian, Jie |
| 英文摘要 | As a molecular imaging technique, bioluminescence tomography (BLT) withits highly sensitive detection and facile operation can significantly reveal molecular and cellular information in vivo at the whole-body small animal level. However, because of complex photon transportation in biological tissue and boundary detection data with high noise, bioluminescent sources in deeper positions generally cannot be localized. In our previous work, we used achromatic or monochromatic measurements and an a priori permissible source region strategy to develop a multilevel adaptive finite-element algorithm. In this paper, we propose a spectrally solved tomographic algorithm with a posteriori permissible source region selection. Multispectral measurements, and anatomical and optical information first deal with the nonuniqueness of BLT and constrain the possible solution of source reconstruction. The use of adaptive mesh refinement and permissible source region based on a posteriori measures not only avoids the dimension disaster arising from the multispectral measured data but also reduces the ill-posedness of BLT and therefore improves the reconstruction quality. Reconsideration of the optimization method and related modifications further enhance reconstruction robustness and efficiency. We also incorporate into the method some improvements for reducing computational burdens. Finally, using a whole-body virtual mouse phantom, we demonstrate the capability of the proposed BLT algorithm to reconstruct accurately bioluminescent sources in deeper positions. In terms of optical property errors and two sources of discernment in deeper positions, this BLT algorithm represents the unique predominance for BLT reconstruction. |
| WOS标题词 | Science & Technology ; Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Engineering ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | DIFFUSE OPTICAL TOMOGRAPHY ; PET OPET SYSTEM ; IN-VIVO ; GENE-EXPRESSION ; TISSUE ; LIGHT ; GEOMETRIES ; ALGORITHM ; MOUSE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000249084000009 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9488]  |
| 专题 | 自动化研究所_09年以前成果 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100080, Peoples R China 2.Xidian Univ, Life Sci Ctr, Xian 710071, Peoples R China 3.Virginia Polytech Inst & State Univ, VT WFU Sch Biomed Engn & Sci, Div Biomed Imaging, Blacksburg, VA 24061 USA |
| 推荐引用方式 GB/T 7714 | Lv, Yujie,Tian, Jie,Cong, Wenxiang,et al. Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation[J]. PHYSICS IN MEDICINE AND BIOLOGY,2007,52(15):4497-4512. |
| APA | Lv, Yujie.,Tian, Jie.,Cong, Wenxiang.,Wang, Ge.,Yang, Wei.,...&Xu, Min.(2007).Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation.PHYSICS IN MEDICINE AND BIOLOGY,52(15),4497-4512. |
| MLA | Lv, Yujie,et al."Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation".PHYSICS IN MEDICINE AND BIOLOGY 52.15(2007):4497-4512. |
入库方式： OAI收割
来源：自动化研究所
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