Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study
文献类型：期刊论文
| 作者 | Bai, Feng1,2; Zhang, Zhijun1,2; Yu, Hui1,2; Shi, Yongmei1,2; Yuan, Yonggui2; Zhu, Wanlin3,4; Zhang, Xiangrong; Qian, Yun1,2 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2008-06-13 |
| 卷号 | 438期号:1页码:111-115 |
| 关键词 | mild cognitive impairment default-mode resting-state voxel-based morphometry low-frequency fluctuation |
| 英文摘要 | Resting-state functional magnetic resonance imaging (MRI), have revealed coactivation in a distributed network that characterizes the default-mode in the human brain. However, details from resting-state imaging in amnestic type mild cognitive impairment (aMCI) is poorly understand. Regional homogeneity, which characterizes low-frequency blood oxygenation level dependent fluctuation, after statistically controlling for the regional atrophy and age in resting-state, were examined and compared between the two groups. When regional atrophy was controlled, decreased regional homogeneity in posterior cingulate cortex and precuneus still remained significant in aMCI patients. In addition the aMCI subjects displayed several regions of increased homogeneity, typically in right inferior parietal lobule, right fusiform gyrus and bilateral putamen. The impairment of posterior cingulate and precuneus could be an important marker to distinguish aMCI from healthy aging in the resting-state. Moreover, the increased regional homogeneity changes would be consistent with compensation for damage to the medial temporal regions and limbic structures, perhaps by recruitment of alternative regions. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | VOXEL-BASED MORPHOMETRY ; GRAY-MATTER LOSS ; ALZHEIMERS-DISEASE ; MAGNETIC-RESONANCE ; REGIONAL HOMOGENEITY ; EPISODIC MEMORY ; HUMAN BRAIN ; CONNECTIVITY ; FMRI ; HYPOMETABOLISM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257152000025 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9629]  |
| 专题 | 自动化研究所_09年以前成果 |
| 作者单位 | 1.SE Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing 210009, Peoples R China 2.SE Univ, Sch Clin Med, Nanjing 210009, Peoples R China 3.Zhejiang Univ, Dept Math, Hangzhou 310027, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Feng,Zhang, Zhijun,Yu, Hui,et al. Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study[J]. NEUROSCIENCE LETTERS,2008,438(1):111-115. |
| APA | Bai, Feng.,Zhang, Zhijun.,Yu, Hui.,Shi, Yongmei.,Yuan, Yonggui.,...&Qian, Yun.(2008).Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study.NEUROSCIENCE LETTERS,438(1),111-115. |
| MLA | Bai, Feng,et al."Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study".NEUROSCIENCE LETTERS 438.1(2008):111-115. |
入库方式： OAI收割
来源：自动化研究所
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