Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia
文献类型：期刊论文
| 作者 | Zhou, Yuan3 ; Shu, Ni3; Liu, Yong3; Song, Ming3; Hao, Yihui1; Liu, Haihong1; Yu, Chunshui2; Liu, Zhening1; Jiang, Tianzi3
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| 刊名 | SCHIZOPHRENIA RESEARCH
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 100期号:1-3页码:120-132 |
| 关键词 | schizophrenia hippocampus fMRI diffusion tensor tractography functional connectivity anatomical connectivity |
| 英文摘要 | Hippocampus has been implicated in participating in the pathophysiology of schizophrenia. However, the functional and anatomical connectivities between hippocampus and other regions are rarely concurrently investigated in schizophrenia. In the present study, both functional magnetic resonance imaging (fMRI) during rest and diffusion tensor imaging (DTI) were performed on 17 patients with paranoid schizophrenia and 14 healthy subjects. Resting-state functional connectivities of the bilateral hippocampi were separately analyzed by selecting the anterior hippocampus as region of interest. The fornix body was reconstructed by diffusion tensor tractography, and the integrity of this tract was evaluated using fractional anisotropy (FA). In patients with schizophrenia, the bilateral hippocampi showed reduced functional connectivities to some regions which have been reported to be involved in episodic memory, such as posterior cingulate cortex, extrastriate cortex, medial prefrontal cortex, and parahippocampus gyrus. We speculated that these reduced connectivity may reflect the disconnectivity within a neural network related to the anterior hippocampus in schizophrenia. Meanwhile the mean FA of the fornix body was significantly reduced in patients, indicating the damage in the hippocampal anatomical connectivity in schizophrenia. The concurrence of the functional disconnectivity and damaged anatomical connectivity between the hippocampus and other regions in schizophrenia suggest that the functional-anatomical relationship need to be further investigated. (C) 2007 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Psychiatry |
| 研究领域[WOS] | Psychiatry |
| 关键词[WOS] | POSITRON-EMISSION-TOMOGRAPHY ; WHITE-MATTER INTEGRITY ; 1ST-EPISODE SCHIZOPHRENIA ; HUMAN BRAIN ; EPISODIC MEMORY ; DEFAULT MODE ; VOLUME REDUCTIONS ; BOLD SIGNAL ; CORTEX ; FMRI |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254722400011 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9692]  |
| 专题 | 自动化研究所_09年以前成果 |
| 作者单位 | 1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Peoples R China 2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 3.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yuan,Shu, Ni,Liu, Yong,et al. Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2008,100(1-3):120-132. |
| APA | Zhou, Yuan.,Shu, Ni.,Liu, Yong.,Song, Ming.,Hao, Yihui.,...&Jiang, Tianzi.(2008).Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia.SCHIZOPHRENIA RESEARCH,100(1-3),120-132. |
| MLA | Zhou, Yuan,et al."Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia".SCHIZOPHRENIA RESEARCH 100.1-3(2008):120-132. |
入库方式： OAI收割
来源：自动化研究所
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