Altered functional connectivity of primary visual cortex in early blindness
文献类型：期刊论文
| 作者 | Yu, Chunshui2; Liu, Yong1 ; Li, Jun1; Zhou, Yuan1; Wang, Kun1; Tian, Lixia1; Qin, Wen2; Jiang, Tianzi1; Li, Kuncheng2
|
| 刊名 | HUMAN BRAIN MAPPING
 |
| 出版日期 | 2008-05-01 |
| 卷号 | 29期号:5页码:533-543 |
| 关键词 | human brain early blindness resting state functional connectivity primary visual area functional magnetic resonance imaging |
| 英文摘要 | In early blindness, the primary visual area (PVA) loses the ability to process visual information, and shifts to working on the processing of somatosensory input, auditory input, and some higher-level cognitive functions. It has not yet been investigated whether such functional changes can lead to alterations of the functional connectivity between the PVA and other brain areas in resting state. The purpose of this study is to investigate the differences in the functional connectivity of the PVA between early blind and sighted subjects using resting functional MRI data. The altered functional connectivity was identified by comparing the correlation coefficients of the PVA with other brain areas between 16 early blind subjects (blindness onset within I year of age) and 32 gender- and age-matched healthy sighted volunteers. Compared with the sighted, the early blind subjects showed decreased functional connectivity between the left PVA and the bilateral supplementary motor area (SMA), pre- and postcentral gyri, superior parietal lobule, and the left superior and middle temporal gyri. Early blind subjects also showed decreased functional connectivity between the right PVA and the bilateral SMA, pre- and postcentral gyri. Our findings suggest that early deprivation of a single sensory modality induces alterations of functional connectivity between the deprived functional area and other associated brain areas. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | RESTING-STATE ; CONGENITALLY BLIND ; HUMAN BRAIN ; SIGHTED INDIVIDUALS ; ACTIVATION PATTERNS ; ALZHEIMERS-DISEASE ; NETWORK ANALYSIS ; ADAPTIVE-CHANGES ; MENTAL-IMAGERY ; MOTOR CORTEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255673900004 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9698]  |
| 专题 | 自动化研究所_09年以前成果 |
| 作者单位 | 1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 2.Capital Univ Med Sci, Dept Radiol, Xuanwu Hosp, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Chunshui,Liu, Yong,Li, Jun,et al. Altered functional connectivity of primary visual cortex in early blindness[J]. HUMAN BRAIN MAPPING,2008,29(5):533-543. |
| APA | Yu, Chunshui.,Liu, Yong.,Li, Jun.,Zhou, Yuan.,Wang, Kun.,...&Li, Kuncheng.(2008).Altered functional connectivity of primary visual cortex in early blindness.HUMAN BRAIN MAPPING,29(5),533-543. |
| MLA | Yu, Chunshui,et al."Altered functional connectivity of primary visual cortex in early blindness".HUMAN BRAIN MAPPING 29.5(2008):533-543. |
入库方式： OAI收割
来源：自动化研究所
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