Modularity in the genetic disease-phenotype network
文献类型：期刊论文
| 作者 | Jiang, Xingpeng; Liu, Bing ; Jiang, Jiefeng; Zhao, Huizhi; Fan, Ming; Zhang, Jing; Fan, Zhenjie; Jiang, Tianzi
|
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2008-07-23 |
| 卷号 | 582期号:17页码:2549-2554 |
| 关键词 | modularity phenotype/genotype relation classification systems biology |
| 英文摘要 | Similar disease phenotypes are engendered as a result of the modular nature of gene networks; thus we hypothesized that all human genetic disease phenotypes appear in similar modular styles. Network representations of phenotypes make it possible to explore this hypothesis. We investigated the modularity of a network of genetic disease phenotypes. We computationally extracted phenotype modules and found that the modularity is well correlated with a physiological classi. cation of human diseases. We also found correlations between the modularity and functional genomics as well as its connection to drug- target associations. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | HUMAN PHENOME ; DISORDERS ; KNOWLEDGEBASE ; INTERACTOME ; PREDICTION ; DATABASE ; PROJECT ; TISSUES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258112000014 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9703]  |
| 专题 | 自动化研究所_09年以前成果 |
| 作者单位 | Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Xingpeng,Liu, Bing,Jiang, Jiefeng,et al. Modularity in the genetic disease-phenotype network[J]. FEBS LETTERS,2008,582(17):2549-2554. |
| APA | Jiang, Xingpeng.,Liu, Bing.,Jiang, Jiefeng.,Zhao, Huizhi.,Fan, Ming.,...&Jiang, Tianzi.(2008).Modularity in the genetic disease-phenotype network.FEBS LETTERS,582(17),2549-2554. |
| MLA | Jiang, Xingpeng,et al."Modularity in the genetic disease-phenotype network".FEBS LETTERS 582.17(2008):2549-2554. |
入库方式： OAI收割
来源：自动化研究所
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