Combination of dynamic C-11-PIB PET and structural MRI improves diagnosis of Alzheimer's disease
文献类型：期刊论文
| 作者 | Liu, Linwen1,2; Fu, Liping3; Zhang, Xi4; Zhang, Jinming3; Zhang, Xiaojun3; Xu, Baixuan3; Tian, Jiahe3; Fan, Yong1,2 |
| 刊名 | PSYCHIATRY RESEARCH-NEUROIMAGING
 |
| 出版日期 | 2015-08-30 |
| 卷号 | 233期号:2页码:131-140 |
| 关键词 | PET imaging Structural MRI Perfusion Amy loid Alzheimer's disease |
| 英文摘要 | Structural magnetic resonance imaging (sMRI) is an established technique for measuring brain atrophy, and dynamic positron emission tomography with C-11-Pittsburgh compound B (C-11-PIB PET) has the potential to provide both perfusion and amyloid deposition information, It remains unclear, however, how to better combine perfusion, amyloid deposition and morphological information extracted from dynamic C-11-PIB PET and sMRI with the goal of improving the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). We adopted a linear sparse support vector machine to build classifiers for distinguishing AD and MCI subjects from cognitively normal (CN) subjects based on different combinations of regional measures extracted from imaging data, including perfusion and amyloid deposition information extracted from early and late frames of C-11-PIB separately, and gray matter volumetric information extracted from sMRI data. The experimental results demonstrated that the classifier built upon the combination of imaging measures extracted from early and late frames of C-11-PIB as well as sMRI achieved the highest classification accuracy in both classification studies of AD (100%) and MCI (85%), indicating that multimodality information could aid in the diagnosis of AD and MCI. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Clinical Neurology ; Neuroimaging ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychiatry |
| 关键词[WOS] | MILD COGNITIVE IMPAIRMENT ; PITTSBURGH COMPOUND-B ; DIMENSIONAL PATTERN-CLASSIFICATION ; AMYLOID-BETA ; PIB-PET ; IN-VIVO ; FDG-PET ; ASSOCIATION WORKGROUPS ; NATIONAL INSTITUTE ; CEREBRAL PERFUSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000359313300009 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/8895]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Neurol, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Linwen,Fu, Liping,Zhang, Xi,et al. Combination of dynamic C-11-PIB PET and structural MRI improves diagnosis of Alzheimer's disease[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,233(2):131-140. |
| APA | Liu, Linwen.,Fu, Liping.,Zhang, Xi.,Zhang, Jinming.,Zhang, Xiaojun.,...&Fan, Yong.(2015).Combination of dynamic C-11-PIB PET and structural MRI improves diagnosis of Alzheimer's disease.PSYCHIATRY RESEARCH-NEUROIMAGING,233(2),131-140. |
| MLA | Liu, Linwen,et al."Combination of dynamic C-11-PIB PET and structural MRI improves diagnosis of Alzheimer's disease".PSYCHIATRY RESEARCH-NEUROIMAGING 233.2(2015):131-140. |
入库方式： OAI收割
来源：自动化研究所
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