Functional Connectivity Density in Congenitally and Late Blind Subjects
文献类型：期刊论文
| 作者 | Qin, Wen1,2; Xuan, Yun3; Liu, Yong4,5 ; Jiang, Tianzi4,5; Yu, Chunshui1,2
|
| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 25期号:9页码:2507-2516 |
| 关键词 | functional connectivity density functional magnetic resonance imaging occipital cortex sensitive period visual deprivation |
| 英文摘要 | Visual deprivation during different developmental periods leads to different structural and functional alterations in the brain; however, the effects of visual deprivation on the spontaneous functional organization of the brain remain largely unknown. In this study, we used voxel-based functional connectivity density (FCD) analyses to investigate the effects of visual deprivation during different developmental periods on the spontaneous functional organization of the brain. Compared with the sighted controls (SC), both the congenitally blind (CB) and the late blind (LB) exhibited decreased short-and long-range FCDs in the primary visual cortex (V1) and decreased long-range FCDs in the primary somatosensory and auditory cortices. Although both the CB and LB exhibited increased short-range FCD in the dorsal visual stream, the CB exhibited greater increases in the short-and long-range FCDs in the ventral visual stream and hippocampal complex compared with the LB. Moreover, the short-range FCD of the left V1 exhibited a significant positive correlation with the duration of blindness in the LB. Our findings suggest that visual deprivation before the developmental sensitive period can induce more extensive brain functional reorganization than does visual deprivation after the sensitive period, which may underlie an enhanced capacity for processing nonvisual information in the CB. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | PRIMARY VISUAL-CORTEX ; DIFFUSION TENSOR TRACTOGRAPHY ; OCCIPITAL CORTEX ; WHITE-MATTER ; HUMAN BRAIN ; SIGHTED INDIVIDUALS ; CORTICAL ACTIVITY ; SENSITIVE PERIOD ; PARIETAL CORTEX ; HEAD MOTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361464000015 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9008]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China 3.Tianjin Med Univ Gen Hosp, Sch Basic Med Sci, Dept Anat, Tianjin 300052, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Wen,Xuan, Yun,Liu, Yong,et al. Functional Connectivity Density in Congenitally and Late Blind Subjects[J]. CEREBRAL CORTEX,2015,25(9):2507-2516. |
| APA | Qin, Wen,Xuan, Yun,Liu, Yong,Jiang, Tianzi,&Yu, Chunshui.(2015).Functional Connectivity Density in Congenitally and Late Blind Subjects.CEREBRAL CORTEX,25(9),2507-2516. |
| MLA | Qin, Wen,et al."Functional Connectivity Density in Congenitally and Late Blind Subjects".CEREBRAL CORTEX 25.9(2015):2507-2516. |
入库方式： OAI收割
来源：自动化研究所
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