Reduced Cortical Thickness in Mental Retardation
文献类型：期刊论文
| 作者 | Zhang, Yuanchao1; Wu, Yan1; Zhu, Maohu2; Wang, Chao1 ; Wang, Jiaojian1; Zhang, Yun1; Yu, Chunshui3; Jiang, Tianzi1,2
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| 刊名 | PLOS ONE
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| 出版日期 | 2011-12-27 |
| 卷号 | 6期号:12 |
| 英文摘要 | Mental retardation is a developmental disorder associated with impaired cognitive functioning and deficits in adaptive behaviors. Many studies have addressed white matter abnormalities in patients with mental retardation, while the changes of the cerebral cortex have been studied to a lesser extent. Quantitative analysis of cortical integrity using cortical thickness measurement may provide new insights into the gray matter pathology. In this study, cortical thickness was compared between 13 patients with mental retardation and 26 demographically matched healthy controls. We found that patients with mental retardation had significantly reduced cortical thickness in multiple brain regions compared with healthy controls. These regions include the bilateral lingual gyrus, the bilateral fusiform gyrus, the bilateral parahippocampal gyrus, the bilateral temporal pole, the left inferior temporal gyrus, the right lateral orbitofrontal cortex and the right precentral gyrus. The observed cortical thickness reductions might be the anatomical substrates for the impaired cognitive functioning and deficits in adaptive behaviors in patients with mental retardation. Cortical thickness measurement might provide a sensitive prospective surrogate marker for clinical trials of neuroprotective medications. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | VOXEL-BASED MORPHOMETRY ; SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; FRAGILE-X-SYNDROME ; DENDRITIC SPINE ; WORKING-MEMORY ; LEARNING-DISABILITY ; INTELLECTUAL DISABILITY ; COMORBID SCHIZOPHRENIA ; DEVELOPMENTAL DELAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300674900052 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/9732]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Univ Elect Sci & Technol China, Key Lab NeuroInformat Minist Educ, Sch Life Sci & Technol, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing, Peoples R China 3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yuanchao,Wu, Yan,Zhu, Maohu,et al. Reduced Cortical Thickness in Mental Retardation[J]. PLOS ONE,2011,6(12). |
| APA | Zhang, Yuanchao.,Wu, Yan.,Zhu, Maohu.,Wang, Chao.,Wang, Jiaojian.,...&Jiang, Tianzi.(2011).Reduced Cortical Thickness in Mental Retardation.PLOS ONE,6(12). |
| MLA | Zhang, Yuanchao,et al."Reduced Cortical Thickness in Mental Retardation".PLOS ONE 6.12(2011). |
入库方式： OAI收割
来源：自动化研究所
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